Wild chimpanzees seek out medicinal plants to treat illness and injuries

Potentially medicinal plants

The authors of the present study combined behavioral observations of wild chimpanzees (Pan troglodytes) with pharmacological testing of the potentially medicinal plants they eat. They monitored the behavior and health of 51 chimpanzees from two habituated communities in the Budongo Central Forest Reserve in Uganda.

Next, they collected plant extracts from 13 species of trees and herbs in the reserve that they suspected the chimpanzees might be using to self-medicate, and tested them for their anti-inflammatory and antibiotic properties. These included plants that they observed sick or injured chimpanzees eating, but were not part of their normal diet, and plants that previous research has suggested chimpanzees might consume for their medicinal properties.

Antibacterial and anti-inflammatory

The researchers found that 88% of the plant extracts inhibited bacterial growth, while 33% had anti-inflammatory properties. Dead wood from a tree in the Dogbane family (Alstonia boonei) showed the strongest antibacterial activity and also had anti-inflammatory properties, suggesting that it could be used to treat wounds.

Bark and resin from the East African mahogany tree (Khaya anthotheca) and leaves from a fern (Christella parasitica) exhibited potent anti-inflammatory effects. The researchers observed a male chimpanzee with an injured hand seek out and eat leaves of the fern, which may have helped to reduce pain and swelling. They also recorded an individual with a parasitic infection consuming bark of the cat-thorn tree (Scutia myrtina).

Drug discovery

The results suggest that chimpanzees seek out specific plants for their medicinal effects. The study is one of the first to provide both behavioral and pharmacological evidence of the medicinal benefits to wild chimpanzees of feeding on bark and dead wood. The medicinal plants growing in Budongo Central Forest Reserve could also be helpful for the development of new drugs to address the challenges of antibiotic resistant bacteria and chronic inflammatory diseases, the authors say.

The authors add: “In this paper, we demonstrate how watching and learning from our primate cousins may fast-track the discovery of novel medicines, while also emphasizing the importance of protecting our forest pharmacies.”