All Pharmaceutical Microbiology articles
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NewsResearchers discovered replication hubs for human norovirus
Researchers have reported the discovery of replication hubs for human norovirus, which could lead to designing antiviral drugs to prevent, control or treat these infections.
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NewsTinkering with the ‘clockwork’ mechanisms of life
Scientists have successfully recreated and validated two distinct mechanisms that can program both the activation and deactivation rates of nanomachines in living organisms across multiple timescales.
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NewsNature’s instructions: How fungi make a key medicinal molecule
Scientists outline how they deciphered nature’s own instructions — namely, the genes of the mold Penicillium citrinum — to discover a previously unreported enzyme that catalyzes the creation of cyclopentachromone-containing compounds.
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NewsApplication of heavy-ion irradiation mutagenesis to improve the production efficiency of the antifungal drug micafungin
Scientists have used heavy-ion irradiation to improve efforts to produce the semisynthetic echinocandin antifungal agent micafungin which derives from fungal natural product FR901379 produced by Coleophoma empetri.
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NewsDiscovery of β‐nitrostyrene derivatives as potential quorum sensing inhibitors for biofilm inhibition in Serratia marcescens
A new study has identified β‐nitrostyrene derivatives as potential quorum sensing inhibitors for biofilm inhibition and antivirulence factor therapeutics against Serratia marcescens.
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NewsScientists offer user manual for yeast’s genetic switches
Scientists have found three gene regulation design principles that provide a flexible guideline for the effective control of microbiological production using yeast.
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NewsNew discovery provides hope in fighting drug-resistant malaria
Researchers have described how they may have found a new target in Plasmodium falciparum, the deadliest malaria parasite: a cholesterol-managing protein called PfNCR1.
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NewsStudy shows drop in use of antiviral medications in young children with influenza
Despite national medical guidelines supporting the use of antiviral medications in young children diagnosed with influenza, a recent study reports an underuse of the treatment.
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NewsNew guidelines unveil advanced strategies for HIV treatment and prevention
The International Antiviral (formerly AIDS) Society-USA (IAS-USA) has published new international guidelines for the treatment and prevention of HIV, based on significant advances in antiretroviral therapies and new prevention strategies such as pre-exposure prophylaxis.
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NewsBreakthrough of the Year: A drug that prevents HIV infection, providing six months of protection per shot
As its 2024 Breakthrough of The Year, Science has named the development of lenacapavir – a promising new injectable drug that prevents HIV infection. The award also recognizes related work surrounding gaining a new understanding of the structure and function of HIV’s capsid protein.
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NewsA new class of antivirals could help prevent future pandemics
A new study introduces a proof-of-concept for a novel class of antivirals that would target a type of enzyme essential not just to SARS, but also many RNA viruses, including Ebola and dengue, as well as cytosolic-replicating DNA viruses, including Pox viruses.
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News‘Superman’ bacteria offer a sustainable boost to chemical production
A new study is focused on making industrial bacteria more robust and useful by reducing the energy, time, and unwanted chemicals required to maintain bacteria, while also making them reusable so they can work longer before needing to be replaced.
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NewsTiny dancers: Scientists synchronise bacterial motion
Researchers have discovered that E. coli bacteria can synchronise their movements, creating order in seemingly random biological systems.
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NewsPeat-bog fungi produce substances that kill tuberculosis-causing bacteria
An analysis of fungi collected from peat bogs has identified several species that produce substances toxic to the bacterium that causes the human disease tuberculosis.
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NewsBacteria ditch tags to dodge antibiotics
Bacteria modify their ribosomes when exposed to widely used antibiotics, according to new research. The subtle changes might be enough to alter the binding site of drug targets and constitute a possible new mechanism of antibiotic resistance.
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NewsResearchers develop lysosomal TRAP for clearance of viruses and variants
Researchers have developed a novel lysosomal strategy for clearing viruses and their variants. This lysosomal ‘TRAP’ (lysoTRAP) shows potential for inhibiting infection by viruses and variants in cell, mouse, hamster, and human lung organoid models.
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NewsParkinson’s drug changes the gut microbiome for the worse due to iron deficiency
Scientists have revealed that the widely prescribed Parkinson’s disease drug entacapone significantly disrupts the human gut microbiome by inducing iron deficiency.
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NewsProbiotic delivers anticancer drug to the gut
Researchers have engineered a probiotic that delivers immunotherapy directly to the gut to shrink tumors in mice, offering a potentially promising oral drug for hard-to-reach cancers.
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Careers‘It’s been an eye-opener’: Thomas Thompson on his year as a Junior Editor
One year into our first Junior Editor training programme with Letters in Applied Microbiology, Dr Thomas Thompson of Queen’s University Belfast tells us how he is getting on.
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NewsWomen’s health company Freya Biosciences announces key $10.4m strategic investment
Freya Biosciences, a transatlantic biotech company specializing in women’s health, has announced a major strategic investment which will be used to develop microbial immunotherapies for the treatment of bacterial vaginosis.
