All Pharmaceutical Microbiology articles
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NewsCancer drug repurposed to treat drug-resistant herpes
Researchers have successfully repurposed an FDA-approved cancer drug, doxorubicin, to treat drug-resistant strains of herpes. A digital tool that combs through chemical compounds and flags those that may be effective against herpes infections, identified doxorubicin, a known anticancer drug.
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NewsMachine learning identifies antimicrobial peptide candidate for ulcerative colitis
Scientists applied machine learning to accelerate AMP discovery and identify candidates with therapeutic potential for ulcerative colitis.
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NewsWhy some people naturally control HIV even after stopping therapy — and how we can leverage that to treat others
New research offers a path toward life without daily HIV pills, suggesting a common diabetes pill could help achieve long-term remission.
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NewsPromising active substance against hepatitis E identified
A drug that is already in clinical trials against hepatitis C virus can also prevent hepatitis E virus from replicating An international research team has filtered bemnifosbuvir, a nucleotide/nucleoside analogue, out of a library of active substances.
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NewsTarget behind cancer drug shown to help fight influenza in mice
A protein already targeted by FDA-approved cancer drugs may also help the body fight influenza. A study found that Programmed Death-Ligand 1 (PD-L1), best known for helping tumors evade immune attack, instead helped immunocompromised mice clear flu-infected lung cells and survive infection.
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NewsNew drug candidate extremely effective against H. pylori bacterium
Researchers have discovered that metronidazole targets two central protective proteins of Helicobacter pylori: an enzyme responsible for detoxifying harmful reactive oxygen species and a protein that repairs damaged proteins.
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NewsEngineered bacteria deliver cancer drug directly inside tumors in mice
New research suggests that Escherichia coli Nissle 1917 (EcN) may be engineered with anticancer agents to treat cancerous tumors in mice. Researchers used EcN as a base for synthesizing Romidepsin (FK228), an FDA-approved drug with anti-tumor agents.
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NewsScientists reveal valuable secrets of Pacific coral reefs
An international consortium of scientists has uncovered new insights into coral ecosystems, revealing that different coral species host their own distinct communities of microbes. They show that coral reefs harbour diverse microbes and produce chemicals with promising potential.
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NewsPlastic bottles transformed into Parkinson’s drug using bacteria
A drug to treat Parkinson’s disease can be made from waste plastic bottles using a pioneering method. The approach harnesses the power of bacteria to transform post-consumer plastic into L-DOPA, a frontline medication for the neurological disorder.
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NewsMedicinal plants with anti-entamoeba histolytica activity: phytochemistry, efficacy, and clinical potential
Reported adverse effects associated with the current first-line treatment for amoebiasis, coupled with the evolution of resistance to it, call for the need to search for plant-based alternatives. This study systematically reviews medicinal plants with activity against Entamoeba histolytica.
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NewsSeaweed has the potential to create a shield to block norovirus infection
Seaweed has certain properties which have the ability to create a shield within the human body, effectively blocking norovirus infection. Fucoidan, from brown seaweed, showed the strongest and most consistent blocking activity against two major norovirus strains, GII.4 and GII.17.
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NewsEnteroBiotix announces completion of enrolment in Phase 2a Trial evaluating EBX-102-02 prior to allogeneic stem cell transplantation
EnteroBiotix announced that the investigator-initiated Phase 2a MAST trial has completed its enrolment of 50 adult patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT) for defined haematological malignancies.
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NewsNew compound stops common complications after intestinal surgery
Researchers have synthesized and tested a new compound in mice that shows promise in protecting the liver from damage and improving nutrient absorption after small bowel resection. They also found that the drug works only on the gastrointestinal tract.
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NewsStudy finds natural fungal supplement improves COVID-19 vaccine response
Researchers have found that a natural fungal supplement taken at the time of COVID-19 vaccination reduced short-term vaccine side effects and helped antibodies last longer in people who had not previously been exposed to the virus.
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NewsChemically ‘stapled’ peptides used to target difficult-to-treat cancers
Researchers have developed a new technology that uses bacteria to build, chemically stabilise, and test millions of potential drug molecules inside living cells. The bacteria produce vast libraries of peptide molecules, and chemically stabilise them into defined shapes while they are being tested inside the cell.
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NewsUltrasound-activated ‘nanoagents’ kill superbugs hiding in biofilms
Scientists have designed nanoagents that act like smart drug‑delivery capsules – carrying an antibiotic deep into bacterial infection sites and releasing it only when activated by gentle ultrasound.
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NewsImaging technique is step towards needed treatments for hantaviruses in new molecular ma
Researchers have produced a detailed blueprint, the highest resolution yet, for a protein complex the Andes virus uses to infect host cells. The new detailed structural information enabled the researchers to produce a vaccine candidate that caused mice to produce neutralizing antibodies against the Andes virus.
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NewsAcoziborole Winthrop receives European Medicines Agency positive opinion as three-tablet, single-dose treatment for most common form of sleeping sickness
The European Medicines Agency has granted a positive opinion to Acoziborole Winthrop (acoziborole) as a single-dose oral treatment for both early- and advanced-stage gambiense sleeping sickness in adults as well as in adolescents 12 years and older weighing at least 40 kilograms.
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NewsScientists identify key protein that stops malaria parasite growth
An international team of scientists have identified a unique protein essential for the malaria parasite’s survival and transmission. Aurora-related kinase 1 (ARK1) acts as a ‘traffic controller’ during the parasite’s unusual cell division and growth process.
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NewsScientists uncover mechanism used by three bacteria-killing viruses to target transporter
Biochemists have homed in on an underexplored small transporter called MurJ that is a vital part of the pathway bacteria use to build their chain-mail-like cell wall. Using advanced tools, the scientists have determined the common mechanism used by three different bacteria-killing viruses to block MurJ from doing its job.