All Pharmaceutical Microbiology articles
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New therapy may effectively control HIV in Uganda
Clinical trials showed an effective antiviral drug, known as lenacapavir, against HIV in Uganda, and has also been tested for drug resistance in different subtype strains.
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Ground-breaking technique deploys bacterium to deliver drugs directly to the brain
A landmark study using the nasal bacteria technique promises new treatments for neurological disorders by bypassing the blood-brain barrier.
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New modeling approach could help design antivirals for shape-shifting viruses
New research utilizes an innovative computational modeling approach to capture the complex and diverse shapes that viral proteins can adopt.
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Researchers engineer biological reaction crucibles to rapidly produce proteins
Biomedical engineers have demonstrated a new synthetic approach that turbocharges bacteria into producing more of a specific protein, even proteins that would normally destroy them, such as antibiotics.
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From Spanish flu to today: how immune cells keep up with a changing virus
In a breakthrough for influenza research, scientists have discovered immune cells that can recognise influenza (flu) viruses even as they mutate, raising hopes for a longer-lasting vaccine and a universal protection against future flu pandemics.
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Breakthroughs in TB vaccine and drug development pave way for global health advancements
An international team of researchers unveils groundbreaking progress in TB vaccine development and therapeutic innovations, offering hope to curb the disease’s devastating impact.
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New study uncovers key differences in allosteric regulation of cAMP receptor proteins in bacteria
A new study provides key insights into how bacterial cAMP receptor proteins (CRPs) respond differently to the ubiquitous signaling molecule, cyclic AMP (cAMP), challenging the assumption that structural similarity predicts functional behavior in allosteric proteins.
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Researchers discover new way to customize living materials for tissue engineering, drug delivery and 3D printing
Researchers have revealed novel sequence-structure-property relationships for customizing engineered living materials (ELMs), enabling more precise control over their structure and how they respond to deformation forces like stretching or compression.
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First success in overcoming gene therapy challenges deploys nanomachines loaded with wine ingredients
Scientists have demonstrated the ability to overcome significant challenges in gene therapy using adeno-associated virus vectors (AAV) by employing a novel smart nanomachine equipped with AAV.
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Nasal COVID-19 vaccine to enter US clinical trials
A nasal vaccine for COVID-19 is poised to enter a phase 1 clinical trial in the U.S. after an investigational new drug application from Ocugen, Inc. was approved by the Food and Drug Administration (FDA).
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NIH-funded clinical trial will evaluate new dengue therapeutic
A clinical trial is testing an experimental treatment designed to help people suffering the effects of dengue. An investigational therapeutic will be administered to adult volunteers who have been exposed to a weakened strain that causes a mild form of the disease.
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Gene found in rough Salmonella Infantis variant offers drug target for variety of pathogens
A new study identifies a gene in a rough Salmonella Infantis variant that could offer a target for developing effective vaccines and therapeutic strategies, not only for Salmonella but other Enterobacteriaceae as well.
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Study yields new insights into the immunomodulatory properties of russula polysaccharides
A new study investigates the structural characteristics and immunomodulatory activities of polysaccharides extracted from Russula vinosa Lindblad using KOH, highlighting the potential of these polysaccharides for applications in pharmaceuticals and functional foods.
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V-161: A breakthrough in the fight against antibiotic-resistant VRE infections
Researchers from Japan have identified V-161, a compound that inhibits Enterococcus hirae V-ATPase activity, disrupting Na+ transport and effectively inhibiting VRE growth.
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Scientists synthesize a promising mushroom-derived compound
Researchers have successfully developed the first method to synthesize inaoside A, a compound derived from the edible mushroom Laetiporus cremeiporus.
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Study of hemp microbiomes may lead to more sustainable farming methods
A new study of hemp microbes may help scientists create special mixtures of helpful microbes to make hemp plants produce more CBD or have better-quality fibers.
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New insights offer hope for developing antiviral therapeutics targeting mpox
New research provides novel perspectives on the biological function of G4s in the lifecycle of MPXV and offer potential avenues for developing antiviral therapeutics targeting mpox prevention and treatment.
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Scientists explain how a compound from sea sponge exerts its biological effects
Girolline, a compound extracted from the sea sponge Pseudaxinyssa cantharella, has been investigated for possible antitumor effects and also found to have anti-malarial effects. Now researchers have a better idea of how it works.
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Small antibody offers broad protection against influenza
Researchers have discovered an antibody-like molecule that can protect mice from various influenza viruses. The findings could pave the way for new treatments and the development of broader influenza vaccines.
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CARB-X funds Peptilogics to develop a novel, broad-spectrum therapeutic to treat fracture-related infections
CARB-X will award Peptilogics US$3.3 million to develop and execute a workplan for its slow-release formulation of a novel, broad-spectrum therapeutic, zaloganan-CR, an engineered peptide intended for use in preventing infection after high-energy-traumatic bone injuries.