All Pharmaceutical Microbiology articles
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NewsAI finds hundreds of potential antibiotics in snake and spider venom
Researchers used a deep-learning system to sift through a database of more than 40 million venom encrypted peptides (VEPs). In a matter of hours, the algorithm flagged 386 compounds with the molecular hallmarks of next-generation antibiotics.
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NewsEmerging viral threats combatted by a potent new dual lipid kinase inhibitor
Lipid kinases play a critical role in cell signalling and membrane trafficking by phosphorylating lipid molecules in the body. The inhibition of two of these lipid kinases, PIKfyve and PIP4K2C, could be beneficial in the treatment of diseases, particularly emerging viruses.
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NewsScientists discover compounds that help cells fight a wide range of viruses
Researchers have identified compounds that can fight off viral infection by activating a defense pathway inside host cells. These compounds, they believe, could be used as antiviral drugs that work against not just one but any kind of virus.
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NewsPenicillium hispanicum yields discovery of new bianthrones and chlorinated bianthrones with cytotoxic activity against cancer cells
A new study reports the discovery of three novel racemic bianthrones from Penicillium hispanicum LA032 using HSQC-based DeepSAT, as well as their cytotoxic evaluation and mechanistic investigation through network pharmacology.
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NewsAnti-cancer drug shows promise against tick-borne virus
Researchers have offered fresh insights into how Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), an emerging tick-borne pathogen, opposes host apoptosis signaling.
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NewsSubstances isolated from marine sponges show potential for treating malária
In pre-clinical tests, compounds called batzelladins were found to be effective even against strains of Plasmodium that are resistant to conventional antimalarial drugs.
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NewsScientists ID new drug target for treating cancer and viral infections
An international team of researchers has identified a molecular mechanism that regulates the activity of N-myristoyltransferases, enzymes that ensure the proteins’ function by chemically modifying them during their production.
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NewsChameleon plant polysccharide targets acute pneumonia with H1N1 and MRSA coinfection
A new study discusses how an anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–lung axis and NLRP3 inflammasome activation.
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NewsAI used to create protein that kills E. coli
Scientists have used artificial intelligence (AI) to generate a ready-to-use biological protein that can kill antibiotic resistant bacteria like E. coli.
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NewsInsights for future research and practical approaches in truncal acne
In a new study, researchers have systematically described the mechanisms of truncal acne, evaluated the methods and evaluated the mechanisms, targets, and pros/cons of several treatment products to guide clinical choices.
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NewsFlightpath Biosciences licenses microbiome-sparing antibiotic developed at Illinois
Flightpath Biosciences, Inc., has licensed a class of antibiotics developed at the University of Illinois Urbana-Champaign. The original antibiotic agent, lolamicin, effectively treated bacterial infections in animal models of disease without wiping out beneficial gut microbes.
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NewsClinical trials reveal promising alternatives to high-toxicity tuberculosis drug
Research shows two novel antibiotics could spare patients from severe side effects. The drugs sutezolid and delpazolid have demonstrated strong antimicrobial activity and a notably better safety profile compared to linezolid.
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NewsCancer-fighting herpes virus shown to be an effective treatment for some advanced melanoma
A genetically engineered herpes simplex virus, when combined with immunotherapy, reduces or eliminates tumors in one-third of clinical trial patients, according to a new study.
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NewsTiny antibody has big impact on deadly viruses
Researchers have discovered a strategy to neutralise two lethal viruses for which there is currently no approved vaccine or cure. The team identified the first ever nanobody to work against Nipah and Hendra, henipaviruses which have jumped from animals to people.
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NewsResearchers find compound that inhibits cutaneous HPVs
Researchers have identified a promising new compound that inhibits cutaneous HPV. In lab studies, the compound inhibited viral replication genes in cutaneous HPVs without damaging host cells.
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NewsMediterranean bacteria may harbor new mosquito solution
Researchers recently identified bacteria in Crete producing metabolites that quickly kill mosquito larvae in lab tests. The compounds might be useful for the development of new biopesticides, though developing the right formulations and delivery method remains a challenge.
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NewsNew breakthrough uncovers how to kill ‘zombie’ TB cells resistant to antibiotics
Researchers exposed a library of over 500,000 genetically modified tuberculosis bacteria to two commonly used antibiotics. By analysing the survivors, they pinpointed genes whose disruption significantly reduced the number of surviving persisters.
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NewsStudy reveals engineered bacterial vesicles to combat antimicrobial resistance
Researchers studying extracellular vesicles (EVs)-membrane-bound nanoparticles released by cells that transport biologically active molecules like proteins or nucleic acids have engineered EVs derived from lactic acid bacteria to carry pathogen-specific endolysins on their surface.
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NewsFirst systematic review finds gut-brain axis impacts treatment outcomes in bipolar patients
A new review suggests that there is a significant connection between the gut and brain in patients treated for bipolar disorder and that this affects the ways in which a patient responds to treatment.
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NewsStudy validates DenovAI’s platform for programmable de novo-designed protein therapeutics
Researchers introduce a new class of experimentally validated AI-driven protein design tools that have the potential to accelerate drug development.