One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
From gut to lung: A microbial signal that strengthens early immune defense
Researchers report that a gut microbiota–derived metabolite can directly shape immune responses in bacterial pneumonia. Using a Klebsiella pneumoniae infection model, the team demonstrated that butyric acid restores the function of CX3CR1-positive natural killer cells.
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NewsHow periodontitis-linked bacteria accelerate osteoporosis-like bone loss through the gut
Researchers reveal that salivary bacteria from gum disease alter gut metabolism, driving osteoclast activity and systemic bone loss. They analyzed salivary microbiota from individuals with advanced periodontitis and compared them with samples from periodontally healthy donors.
NewsGut microbiome connected with heart disease precursor
Before the onset of cardiovascular disease symptoms, people often develop dyslipidemia, or abnormal levels of lipids in the blood. Microbiologists have identified microbial taxa more likely to be found in people with dyslipidemia than in people with healthy levels of cholesterol and triglycerides.
NewsAntibacterial coatings with short-term effect may fail over longer periods of time
Researchers have shown that antibacterial coatings which initially appear highly effective at destroying bacteria may lose their performance over time. Therefore, long-term testing is essential for developing the best antibacterial materials.
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News
Targeting the gut–lung microbiome to reduce infections in severe pancreatitis
Researchers report new clinical evidence that a fungal probiotic may reduce hospital-acquired infections in patients with severe acute pancreatitis. Patients receiving Saccharomyces boulardii alongside standard enteral nutrition experienced significantly fewer infections than those receiving nutrition alone.
NewsResearchers identify ‘neuroimmune signature’ that can predict viral hepatitis complications
A network of genes linked to the nervous and immune systems can predict cancer risk and even explain symptoms such as fatigue and depression resulting from viral hepatitis infection.
NewsScientists develop shape-shifting scaffold that fights infection and rebuilds bone
Scientists have developed a body-temperature–responsive, 3D-printed shape-memory scaffold coated with a metal–polyphenol network to treat infectious bone defects. It is designed to adapt to irregular bone defects while providing antibacterial activity, immune regulation, and osteogenic support.
News Thermo Fisher Scientific launches new color-based culture media to help detect Candida infections faster
Thermo Fisher Scientific today announced the launch of Thermo Scientific™ Brilliance™ Candida 2 Agar and Spectra™ Candida Agar, new color-based (chromogenic) culture media to help laboratories quickly detect and differentiate clinically important Candida species.
NewsBacteria found in mouth and gut may help protect against severe peanut allergic reactions
One of the big mysteries in food allergy is why two people with similar levels of peanut specific antibodies can react so differently. A new study shows for the first time how gut bacteria break down parts of an allergenic food and influence how a person reacts to peanuts.
NewsStudy finds natural fungal supplement improves COVID-19 vaccine response
Researchers have found that a natural fungal supplement taken at the time of COVID-19 vaccination reduced short-term vaccine side effects and helped antibodies last longer in people who had not previously been exposed to the virus.
NewsNew tool reveals the secrets of HIV-infected cells
Scientists have developed a novel tool—named HIV-seq—for profiling the features of rare HIV-infected cells from people with HIV. Using the new tool, they’ve found key differences in people’s HIV-infected cells before versus after starting antiretroviral therapy.
NewsChemically ‘stapled’ peptides used to target difficult-to-treat cancers
Researchers have developed a new technology that uses bacteria to build, chemically stabilise, and test millions of potential drug molecules inside living cells. The bacteria produce vast libraries of peptide molecules, and chemically stabilise them into defined shapes while they are being tested inside the cell.
NewsResearchers find a gentler way to treat aggressive gum disease
Researchers have discovered that the primary bacterium driving gum disease carries an internal “genetic brake” that controls its own aggression. By locking this brake in place, future treatments could silence the pathogen while leaving beneficial bacteria untouched.
NewsNanoparticle vaccine approach takes on a new target: Hepatitis C virus
Scientists have engineered a native-like, stabilized version of Hepatitis C virus’s E1E2 complex and used it to build a nanoparticle-based vaccine candidate. It uses a technology called self-assembling protein nanoparticles, which organizes copies of the proteins into virus-like clusters that the immune system can recognize.
NewsDiisobutyl phthalate at environmental concentration promotes conjugative transfer of antibiotic resistance genes
Researchers investigating the ecological safety risks posed by dibutyl phthalate (DBP), in aquatic environments found it significantly increased conjugative transfer frequency in both intragenus (E. coli DH5α to E. coli HB101) and intergenus (E. coli DH5α to B. subtilis WB100N) systems.
NewsToxic algal bloom takes heavy toll on mental health
The year-long algal bloom along the South Australian coastline has not only devastated marine life and triggered health risks for humans and pets: it has also had a significant psychological impact on local residents, according to new research.
NewsBig and small dogs both impact indoor air quality - just differently
An initial study reports that dogs — both big and small — impact indoor air quality. The researchers found that small active dogs produced more airborne particles, but larger animals released more microbes into the air than people did.
NewsTestosterone increases severity of bacterial skin infections
Men are more susceptible than women to skin infections caused by Staphylococcus aureus bacteria, but the biological basis for this disparity has remained unclear. A new study is the first to reveal testosterone, present at higher levels in males, as a key driver of infection.
NewsHuge toll: Bird flu rampant among black vultures
More than four out of every five dead black vultures examined by University of Georgia researchers tested positive for highly pathogenic avian influenza, according to a new study. Their indiscriminate scavenging appears to sustain transmission of the virus beyond the typical bird flu season.
NewsFecal transplants from older mice significantly improve ovarian function and fertility in younger mice
A new study details how fecal transplants from older female mice significantly improve ovarian function and fertility in young mice. The surprising results reveal a direct link between the microbiome of the gut and ovarian health and function.
NewsUltrasound-activated ‘nanoagents’ kill superbugs hiding in biofilms
Scientists have designed nanoagents that act like smart drug‑delivery capsules – carrying an antibiotic deep into bacterial infection sites and releasing it only when activated by gentle ultrasound.
NewsScientists identify therapeutic target that would curb the spread of coronaviruses
Coronaviruses not only use the machinery of the human cells they infect: they modify it to achieve optimal conditions to produce viral proteins and thus spread more quickly, according to a study identifying enzymes that modify transfer RNAs as key elements for coronavirus infection.
NewsCell-free DNA offers early warning for bloodstream infections in kids with leukemia
Researchers show that microbial cell-free DNA sequencing can predict bloodstream infections in children with leukemia days before the symptoms appear. Plasma microbial cell-free DNA sequencing (mcfDNA-Seq) offer a potential approach to protecting vulnerable patients by allowing treatment to start before the patient gets sick.