Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
A study based on blood samples strongly suggests that most persistent cases of viral detection, despite ideal HIV drug therapy, are not due to virus transmission or a rebound of active disease.
Read storyResearchers recently studied associations among green space exposure, mental well-being, and the nasal microbiome—the microbes in a person’s nose. The analysis showed correlations among microbial signatures, time spent outdoors and positive mental well-being.
A new study shows that food insecurity may leave a measurable impact on the gut microbiome of children. Children in food-insecure households had different gut microbiome profiles, including higher levels of Sutterella, which has been linked to poor dietary quality and intestinal inflammation.
Researchers have assessed long-term trends in TORCH infections in India, a region where reliable data have been lacking. TORCH includes pathogens that cause toxoplasmosis, rubella, cytomegalovirus (CMV), herpes simplex virus and other infections.
A new study shows that sewage overflows in homes can expose people to bacteria that can make them sick, including antibiotic-resistant and multidrug resistant bacteria which can make infections difficult to treat.
Infections should be considered a “health hazard” in people living with diabetes, with experts warning that current clinical guidelines fail to reflect a substantial but under-recognised burden of illness, hospitalisation and death. People living with type 1 diabetes, type 2 diabetes and prediabetes face higher risks of infection compared to those without diabetes.
The genetic diversity of hantavirus and the low levels of virus typically found in patient samples make sequencing its genome particularly challenging. Researchers have developed a new, effective, and low-cost way to carry out whole genome sequencing for hantaviruses.
To rebalance the oral microbiome and cure chronic halitosis, researchers are embarking on a first-of-its-kind experiment. These clinical trials transplant bacteria and other microbes from healthy donors into patients with halitosis. If successful, the healthy microbiota will crowd out the bad and patients’ bad breath will improve.
A study has found that vaccination against respiratory syncytial virus (RSV) during pregnancy reduced the risk of hospitalization in young infants by nearly 70%. It provides early real-world evidence from U.S. clinical care, showing that administering one dose of the maternal RSV vaccine (RSVpreF vaccine) reduces hospitalization related to RSV in young infants.
A class of flu drugs may reduce cognitive decline and premature aging in people living with chronic viral infection. Scientists identified a new biological culprit: the degradation of protective sugar molecules in our bodies, known as glycans, that normally help keep inflammation in check.
The DIVINE study database has been published. The cohort includes clinical information from 5,813 patients hospitalised with COVID-19 during four waves of the pandemic, between March 2020 and August 2021, across five hospitals in the southern metropolitan area of Barcelona.
A new study reveals that when the difference between body temperature and the ambient temperature is greater, the clouds of particles generated by coughing or sneezing disperse more and maintain a higher concentration.
Researchers have designed non-toxic Salmonella bacteria to deliver viruses that are safe to humans but potent against liver and pancreatic cancer tumors. Animal models treated with this combination of bacteria and viruses saw almost all their tumors eliminated and lived significantly longer.
A new predictive model could help scientists more efficiently identify the reservoirs of emerging zoonotic viruses and dangerous pathogens like Ebola that can spill over from animals into humans. It relies on detailed information collected on suspected reservoir species to identify key windows.
Different parts of your mouth have entirely different bacterial communities, reveals a new microbial map. Researchers believe mapping these microbial niches will provide a census of the good bacteria present in the mouth and help to develop targeted therapies, such as probiotics, to maintain oral health and prevent disease.
A researcher is refining a powerful therapy for drug-resistant bacteria that pierces the gooey coating that anchors and protects such germs from the drugs we take to kill them. She has found that an antimicrobial peptide naturally found in cows weakens the biofilm defenses of Klebsiella pneumoniae bacteria and destroys it.
Antibiotic residues in agricultural soils are an emerging environmental concern, with potential impacts on soil health, crop safety, and the spread of antimicrobial resistance. A new study reports on an iron-modified biochar that helps soil use its own oxygen and iron chemistry to break down sulfamethoxazole.
Researchers have now come up with a way to modify the injectable polio vaccine so that it can also promote a mucosal immune response. This vaccine could help to achieve polio eradication while avoiding the risks of the oral polio vaccine.
Researchers have discovered a new antibiotic that kills some of the world’s most dangerous and drug-resistant bacteria by targeting a previously unknown vulnerability. Manikomycin has shown early effectiveness against priority pathogens including Salmonella, E. coli, and Klebsiella.
Patients with acid reflux, which occurs when stomach acid pushes up into the esophagus, know the symptoms all too well: heartburn, belching, chest pain and trouble swallowing. Acid reflux also increases the risk of esophageal cancer, but researchers are investigating how a simple probiotic could treat and prevent both conditions.
As antimicrobial resistance accelerates worldwide, leading experts gather in Valencia to address the scientific, regulatory, manufacturing and clinical challenges that will determine whether phage therapy becomes a routine healthcare solution.
Persistently low rates of COVID-19 vaccination in Black and Hispanic children suggest that parents in these communities tend to be hesitant about the vaccine for their kids, even when they have received it themselves. A new study sheds light on the factors influencing decisions about vaccination.
Antibiotics for sore throats have hardly any preventive effect against serious streptococcal infections in the population, according to a study. Instead, healthcare needs to quickly recognize warning signs of a serious infection.