One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
Bacteria incorporate forever chemicals into cell membrane molecules
New research shows that bacteria incorporate polyfluoroalkyl carboxylates—a type of Per- and Polyfluoroalkyl Substances (PFASs)—into the molecules that make up their cell membranes.
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NewsInuit recommendations to address high rates of tuberculosis in Nunavik, Quebec
Tuberculosis rates for Inuit living in Nunavik, the Inuit lands in northern Quebec, are 1,000 times greater than among non-foreign-born Quebeckers, and underresourcing of local health care adds to hardship from the disease, found new research.
NewsA new mouse model of virus-driven liver cancer may open the door to better diagnosis and treatments
Researchers have created the first mouse model in which chronic viral infection progresses to liver cancer, closely mirroring what happens in people with hepatitis C.
NewsNovel treatment protocol targets the deadliest cases of C. difficile infection
A new study demonstrated that fecal microbiota transplantation (FMT) can rapidly reverse systemic inflammation and improve survival in patients with fulminant Clostridioides difficile infection.
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News
New virulence regulator of diarrhea pathogen discovered
While it was already known that RNA molecules enable direct temperature sensing in the model organism Yersinia pseudotuberculosis, a new study reveals that the Fis protein also plays a regulatory role at the DNA level.
NewsShiitake-derived β-glucan inhibits human cervical cancer progression through DMBT1
A team of researchers investigated the molecular mechanism underlying the anti-cervical cancer activity of Lentinus edodes-derived β-glucan (LNT) and, for the first time, identified DMBT1 as a key target.
NewsHigh‑fat diets linked to rapid decline in protective gut immune cells
In a preclinical study, researchers found that even short-term exposure to high levels of dietary fat results in a quick and selective loss of critical gut immune cells called ILC3s, promoting intestinal permeability and inflammation.
NewsCharacteristics of CD4+T-cell reduction and pulmonary infections in critically ill immunocompromised patients
A new study investigates the relationship between reduced CD4+T-cell counts and lung infections in immunosuppressed patients admitted to intensive care units (ICUs).
NewsVanderbilt Center for Antibody Therapeutics signs agreement to develop anti-measles antibody treatment
The Vanderbilt Center for Antibody Therapeutics has signed an option agreement with Saravir Biopharma Inc. for the company to develop human monoclonal antibodies isolated in the laboratory of James Crowe Jr., MD, for the treatment and prevention of measles.
NewsNipah virus hijacks host protein NSUN2 to fuel replication
Researchers have decoded a critical survival strategy of the deadly Nipah virus (NiV), identifying a key host protein hijacked by the pathogen and translating this discovery into a promising new treatment approach.
NewsInterferon therapy found to be well-tolerated in compensated hepatitis B cirrhosis
A multicenter analysis of 920 patients finds no higher risk of serious complications in compensated cirrhosis compared to standard treatment.
NewsOne of cholera’s great enemies is found in the human gut
Cholera-causing bacteria are locked in an evolutionary arms race with a viral nemesis, according to a new genomic study. Researchers found that in the Ganges Delta, cholera bacteria rapidly gain and lose special armour that protects against attacks from the virus, known as bacteriophage ICP1.
NewsOregano, rosemary and ‘time’: Long-term swine study shows natural-compound benefits
In a rare long-term public study that compared the effects of phytochemicals from rosemary and oregano with antibiotic growth promoters, animal scientists found that the natural agents given to weaned pigs supported favorable gut health and growth performance later in their lives.
NewsScientists warn antibacterial soaps and wipes can fuel antimicrobial resistance
An international team of scientists is warning that everyday antibacterial soaps, wipes, sprays, and other “germ‑killing” products are quietly contributing to the global rise of antimicrobial resistance (AMR) while providing no added health benefit for most consumer uses.
NewsRisk of Alzheimer’s dementia significantly reduced after high-dose influenza vaccination compared to the standard dose
The risk of Alzheimer’s disease significantly decreases in older adults who receive a higher dose of the influenza vaccine compared to the standard dose, according to new research.
NewsCommon virus plus mono associated with increased risk of MS
Having the disease infectious mononucleosis, often called mono, caused by the Epstein-Barr virus is associated with an increased risk of developing multiple sclerosis (MS), according to a study.
NewsInfluence of antibiotic use on mental health during pregnancy
New research points to an association between antibiotic exposure and maternal psychological distress in early-to mid-pregnancy.
NewsAir surveillance reveals hidden reservoirs of antibiotic resistance genes
The air we breathe serves as a silent vector of antimicrobial resistance, calling for the need to integrate air monitoring into global public health strategies, according to a review by an international team of researchers.
NewsSmall intestinal bacterial overgrowth - and your allergy symptoms
A review suggests that small intestinal bacterial overgrowth (SIBO) may be associated with symptom exacerbation in atopic diseases, such as bronchial asthma, food allergies, or chronic urticaria.
NewsGlobal Virus Network launches expanded “Global Guardians for Pandemic Preparedness” program for Florida high school students
The Global Virus Network (GVN) announced the launch of its expanded Global Guardians for Pandemic Preparedness initiative, with applications now open for high school students across the state of Florida.
NewsDecoding the chemical messengers: Gut microbes talk to the whole body through metabolites
A comprehensive review systematically maps how bacterial metabolites shape immune responses and diseases across organs.
NewsInequalities in childhood pneumococcal vaccine uptake persist in England despite schedule change
Vaccine uptake data has been examined to assess the impact of moving from a ‘2+1’ to a ‘1+1’ Pneumococcal Conjugate Vaccine (PCV) dose schedule on vaccine coverage and health inequalities among infants in England.
NewsThe tumor microbiota: A new frontier in cancer biology
A new study synthesizes evidence from different types of tumors, particularly those characterized by low microbial biomass, where conclusions require particularly rigorous validation. By outlining a roadmap of experimental and analytical standards, this work provides the basis for more robust research.