One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
Avian flu could push vulnerable vulture populations into further decline
H5N1 avian influenza is emerging as a serious threat to already vulnerable vulture populations, with deaths reported across the Americas and Europe. Researchers warn that losing these scavengers could also weaken a natural barrier against disease by allowing infected carcasses and pathogens to persist for longer.
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NewsMyxobacteria reveal hidden chemistry with anticancer potential
Researchers have uncovered a previously hidden family of natural products made by soil-dwelling myxobacteria and traced how the molecules are assembled. Follow-up work showed that one of these compounds binds to AKR1C3, a human protein linked to several cancers, highlighting the drug-discovery potential of previously silent microbial genes.
NewsMarine compound shows promise against deadly brain-eating amoeba
A compound isolated from a marine bacterium may offer a faster way to attack Naegleria fowleri, the amoeba responsible for one of the deadliest known brain infections. In laboratory tests, rutamycin B reached full potency within four hours and was far more toxic to the parasite than to human cells.
NewsOne Health initiative aims to build safer, more sustainable food systems
A new One Health initiative in Thailand is bringing together expertise across food safety, antimicrobial resistance, climate change and public health. The platform aims to turn scientific evidence into coordinated action across agrifood systems, with a strong focus on collaboration between researchers, government, industry and international partners.
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News
Leaf spectra reveal hidden nitrogen-fixing nodules in soybean roots
Soybean roots may no longer need to be dug up to reveal how well they are forming nitrogen-fixing nodules. Researchers have shown that hyperspectral signals from leaves can predict below-ground nodule traits, offering a non-destructive way to track plant–microbe partnerships under drought and salt stress.
NewsCommon cell-death inhibitor reveals an unexpected pathway in tuberculosis
A widely used cell-death inhibitor may be triggering macrophage death during mycobacterial infection through an unexpected off-target pathway. The findings reveal a caspase-8-independent route to necroptosis and could help explain how damaging necrotic granulomas form during tuberculosis.
NewsDistant climate patterns may offer early warning of Ebola outbreaks
Ebola outbreaks may leave a climatic trail months before they emerge. By analysing nearly five decades of outbreak data alongside large-scale climate oscillations, researchers identified distant weather patterns that could help flag periods and regions where Ebola risk may be increasing.
NewsScientists propose national microbiome plan to prevent chronic disease
Leading microbiome researchers are calling for a global ‘moonshot’ to determine how the microbes living in and on our bodies contribute to chronic disease. The proposed agenda would combine long-term human studies, clinical trials, global research standards and public education to move the field from promising associations towards proven causes and treatments.
NewsGut microbiome may help explain why sleep improvement varies after hydrogen supplementation
Hiroshima University researchers investigated the effects of hydrogen supplementation on sleep quality in healthy human volunteers. While hydrogen supplementation had no significant effect compared to a placebo, individuals in the hydrogen-supplementation group reporting better sleep quality were discovered to have a lower abundance of hydrogen producing bacteria in their gut microbiome.
NewsDrug-resistant bacteria in clinic air raise infection-control concerns
Air sampled inside a South African clinic contained multiple ESKAPE bacteria resistant to commonly used antibiotics, with some surviving even last-resort treatments. The findings raise concerns about airborne exposure in healthcare settings, particularly for patients with weakened immune systems.
NewsHow eggplants ‘farm’ their own microbiomes: Genetic secrets revealed
Eggplants appear to actively shape the microbial communities around their roots through their own genetics. A large global study has identified more than 1,200 genetic variants linked to key root microbes, revealing how crop evolution and domestication may have helped plants recruit beneficial microbial partners.
NewsTwo-in-one tool tracks viral RNA inside live infected cells in real time
The tool lets researchers film activity of Zika and chikungunya viruses in high resolution and identify virus-host interactions, a key step to developing effective antiviral strategies that could stop infections
NewsScientists reveal how deadly Andes hantavirus attaches to human cells
Earlier this year, an outbreak of Andes hantavirus on a cruise ship, which killed three passengers and sickened 13, highlighted the lack of approved vaccines or treatments for the virus. Scientists now show how the virus recognizes its target on a human cell, a finding that could lead to effective therapies against Andes virus and other hantaviruses.
NewsNew dosing data expands HIV treatment options for newborns
Newborns with HIV can now be treated with dolutegravir from the first days of life. An international clinical study identified a safe dosing regimen that produced drug levels comparable to those seen in older children and adults, helping support the FDA’s expanded approval.
NewsHow clinicians can manage recurrent catheter bloodstream infections
Long-term intravenous catheters can be essential for treatment, but they also create a persistent risk of serious bloodstream infections. A new clinical review outlines how doctors can diagnose, treat and prevent recurrent infections while preserving vital vascular access whenever it is safe to do so.
NewsCould climate change have helped Candida auris become a global pathogen?
How did Candida auris become a global health threat so quickly? A new review suggests climate change may be one factor, with rising environmental temperatures potentially favouring fungi that can tolerate the heat of the human body, although researchers stress that the link has not yet been proven.
NewsNeedle-free approach could offer a new way to deliver mRNA vaccines
A needle-free mRNA vaccine delivered through the skin protected mice against both SARS-CoV-2 and influenza while causing less inflammation than lipid-based formulations. The approach uses a high-pressure liquid jet and a combination of two immune-boosting adjuvants to strengthen protection without relying on conventional mRNA carriers.
NewsScientists discover migration-mediated mechanism enabling bacteria-virus coexistence
A study shows how collective movement enables viruses to persist with migrating bacterial colonies while minimizing the risk of either complete viral takeover or bacterial escape.
NewsReindeer grazing reshapes the hidden roots of northern forests
Reindeer grazing is reshaping northern pine forests beneath the surface as well as above it. Researchers found nearly 30% less shallow-root biomass in grazed forests, alongside shorter, thicker and less-branched roots, changes that could alter nutrient uptake, soil microbial communities and the way carbon moves through these ecosystems.
NewsNew architecture for antifungal drug precisely combats fungal infections in mice without the usual toxicity
By applying a unique molecular “scaffold,” researchers have created a broad-spectrum antifungal drug that homes in on a key fungal compound without disrupting the host’s cholesterol – a frequent side effect of current therapies. The compound’s selectivity could help avoid the toxic side effects that have plagued antifungal therapy regimens for decades.
NewsChildhood measles vaccination rates fall worldwide post COVID-19
Routine vaccine program disruptions and under-resourced health systems are driving a global decline in childhood measles vaccination rates post COVID-19, a study has found.
NewsArmored cells: A mineral shell lets whole-cell biocatalysts run 14 cycles for greener nicotinic acid
Scientists aiming to use whole-cell biocatalysis to manufacture niacin engineered Corynebacterium glutamicum to express a mutant nitrilase from Pseudomonas putida and then encapsulated the whole cells in a biomimetic hybrid shell.
NewsScientists create white blood cell with memory of how to fight off winter flu bugs
Scientists have started work on a new way to fight cold and flu viruses by reprogramming the cells in our immune system to respond faster to infections. They are developing a type of white blood cell, called killer cells, with a pre-installed memory of how to fight off respiratory diseases.