All Vaccinology articles – Page 3
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Seasonal flu vaccine study reveals host genetics’ role in vaccine response
Scientists have found that influenza subtype-bias is primarily driven by host genetics, particularly major histocompatibility complex (MHC) class-II polymorphisms, with prior exposure playing a secondary role.
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‘Unbreakable’ Lassa vaccine shows promising results
A live-attenuated vaccine candidate against Lassa virus completely protected guinea pigs exposed to an otherwise lethal dose of the virus, researchers have reported.
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Pediatric investigation study confirms the safety of COVID-19 vaccination during pregnancy
A new study shows that maternal COVID-19 vaccination is not associated with adverse health outcomes in infants.
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Cases of whooping cough growing, but knowledge about it is lacking
Many in the public are not familiar with symptoms of whooping cough. Almost a third of respondents (30%) are not sure if pertussis is the same as whooping cough and not sure (30%) whether a vaccine exists to prevent it.
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Staphylococcus aureus thwarts vaccines by turning on a protein that halts immune response
Approximately 30 clinical trials to date have failed to result in an effective human vaccine for Staphylococcus aureus but researchers have now identified a key reason for these failures, indicating that it may be possible to modify the vaccines to work in humans.
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Initiative to start HPV vaccination at age 9 improved completion rates
A quality improvement program designed to increase earlier uptake of the human papillomavirus (HPV) vaccine raised vaccination rates significantly, according to a study.
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Study finds widening inequalities in child vaccination rates across England
Vaccine uptake was found to be consistently lower among children in areas of higher deprivation, while the number of children susceptible to measles at age 5 increased 20-fold in the most deprived areas.
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Scientists transform ubiquitous skin bacterium into a topical vaccine
Researchers have domesticated of a bacterial species that hangs out on the skin of close to everyone on Earth to create a vaccine that is a cream instead of needle.
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Updated Hep B vaccine more effective for people with HIV
A newer vaccine against hepatitis B virus was clearly superior to an older vaccine type in inducing a protective antibody response among people living with HIV who didn’t respond to prior vaccination, according to an international study.
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Possible colon cancer vaccine target uncovered in bacteria
Higher rates of certain cancers may be linked to two particular strains of bacteria. Targeting these with treatments or vaccines could help reduce the risk of colorectal, bladder, and prostate cancers.
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Researchers find rotavirus vaccine is safe for use in NICU babies
Transmission of rotavirus vaccine strains in a neonatal intensive care unit (NICU) is rare and without clinical consequences, suggesting that giving the rotavirus vaccine to eligible infants during their hospitalization provides immune benefits that outweigh any risks.
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New hope in the fight against Hepatitis C: Broadly effective innovative vaccine design
Epitope-focused immunogens in mouse models with a human antibody repertoire triggered a robust immune response in a new study. The produced antibodies were capable of successfully neutralizing multiple genetically diverse HCV strains.
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Cervical cancer deaths in young women plummet after introduction of HPV vaccine
Cervical cancer deaths have plunged dramatically among women under age 25, and researchers believe this is likely due to HPV vaccination.
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Simple COVID-19 vaccine can be stored at room temperature and administered as a nasal spray
Researchers have developed an effective, inexpensive, and simple COVID-19 vaccine that can be stored at room temperature and administered as a nasal spray.
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How protective antibodies get in malaria’s way
Researcher’s structural insights help reveal weak spot in parasite’s plan of attack which could help guide vaccine design.
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Researchers use biophysics to design new vaccines against RSV and related respiratory viruses
Scientists improved existing vaccines by analyzing the molecular structure and stability of viral proteins.
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New nasal vaccine shows promise in curbing whooping cough spread
As whooping cough cases rise in the U.S., a new nasal vaccine developed by Tulane University may hold the key to reducing the spread of the highly contagious respiratory disease. Source: Medical Illustrator: Dan Higgins Medical illustration of drug-resistant Bordetella pertussis bacteria Current pertussis vaccines are widely ...
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Measles cases surge worldwide, infecting 10.3 million people in 2023
Worldwide, there were an estimated 10.3 million cases of measles in 2023, a 20% increase from 2022, inadequate immunization coverage globally is driving the surge in cases.
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Potential single-dose smallpox and mpox vaccine moves forward
Scientists report on studies suggesting that the horsepox virus in the experimental vaccine is substantially more attenuated—and less likely to trigger a systemic infection—than the vaccinia virus used in the single-dose vaccine already approved by the FDA.
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Study reveals best timing for getting the RSV vaccine during pregnancy to protect newborns
Researchers found that getting vaccinated on the early side of the recommended window was best for transferring maternal antibodies to the fetus.