All Vaccinology articles
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Hepatitis E vaccination is effective in an epidemic
A case-control study has proved the effectiveness of the two-doses Hecolin vaccine against a potential hepatitis E outbreak.
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Promising COVID-19 vaccine development in animal trials
Researchers developed a COVID-19 vaccine that deploys virus-like particles (VLPs) for immunity stimulation in mice.
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T cells’ capability to fully prevent acute viral infections opens new avenues for vaccine development
Scientists have discovered that T cells—white blood cells that can destroy harmful pathogens—can completely prevent viral infection, to an extent previously thought only possible due to neutralising antibodies.
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Small antibody offers broad protection against influenza
Researchers have discovered an antibody-like molecule that can protect mice from various influenza viruses. The findings could pave the way for new treatments and the development of broader influenza vaccines.
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Self-destructing vaccine offers enhanced protection against tuberculosis in monkeys
A self-destructing vaccine administered intravenously provides additional safety and protection against tuberculosis (TB) in macaque monkeys, suggests new research.
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Virus that threatened humanity opens the future
Researchers have developed an innovative therapeutic platform by mimicking the intricate structures of viruses using artificial intelligence.
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Seasonal flu vaccine study reveals host genetics’ role in vaccine response
Scientists have found that influenza subtype-bias is primarily driven by host genetics, particularly major histocompatibility complex (MHC) class-II polymorphisms, with prior exposure playing a secondary role.
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‘Unbreakable’ Lassa vaccine shows promising results
A live-attenuated vaccine candidate against Lassa virus completely protected guinea pigs exposed to an otherwise lethal dose of the virus, researchers have reported.
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Pediatric investigation study confirms the safety of COVID-19 vaccination during pregnancy
A new study shows that maternal COVID-19 vaccination is not associated with adverse health outcomes in infants.
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Cases of whooping cough growing, but knowledge about it is lacking
Many in the public are not familiar with symptoms of whooping cough. Almost a third of respondents (30%) are not sure if pertussis is the same as whooping cough and not sure (30%) whether a vaccine exists to prevent it.
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Staphylococcus aureus thwarts vaccines by turning on a protein that halts immune response
Approximately 30 clinical trials to date have failed to result in an effective human vaccine for Staphylococcus aureus but researchers have now identified a key reason for these failures, indicating that it may be possible to modify the vaccines to work in humans.
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Initiative to start HPV vaccination at age 9 improved completion rates
A quality improvement program designed to increase earlier uptake of the human papillomavirus (HPV) vaccine raised vaccination rates significantly, according to a study.
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Study finds widening inequalities in child vaccination rates across England
Vaccine uptake was found to be consistently lower among children in areas of higher deprivation, while the number of children susceptible to measles at age 5 increased 20-fold in the most deprived areas.
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Scientists transform ubiquitous skin bacterium into a topical vaccine
Researchers have domesticated of a bacterial species that hangs out on the skin of close to everyone on Earth to create a vaccine that is a cream instead of needle.
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Updated Hep B vaccine more effective for people with HIV
A newer vaccine against hepatitis B virus was clearly superior to an older vaccine type in inducing a protective antibody response among people living with HIV who didn’t respond to prior vaccination, according to an international study.
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Possible colon cancer vaccine target uncovered in bacteria
Higher rates of certain cancers may be linked to two particular strains of bacteria. Targeting these with treatments or vaccines could help reduce the risk of colorectal, bladder, and prostate cancers.
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Researchers find rotavirus vaccine is safe for use in NICU babies
Transmission of rotavirus vaccine strains in a neonatal intensive care unit (NICU) is rare and without clinical consequences, suggesting that giving the rotavirus vaccine to eligible infants during their hospitalization provides immune benefits that outweigh any risks.
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New hope in the fight against Hepatitis C: Broadly effective innovative vaccine design
Epitope-focused immunogens in mouse models with a human antibody repertoire triggered a robust immune response in a new study. The produced antibodies were capable of successfully neutralizing multiple genetically diverse HCV strains.
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Cervical cancer deaths in young women plummet after introduction of HPV vaccine
Cervical cancer deaths have plunged dramatically among women under age 25, and researchers believe this is likely due to HPV vaccination.
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Simple COVID-19 vaccine can be stored at room temperature and administered as a nasal spray
Researchers have developed an effective, inexpensive, and simple COVID-19 vaccine that can be stored at room temperature and administered as a nasal spray.