All Vaccinology articles
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Study: Experimental bird flu vaccine excels in animal models
A vaccine has demonstrated complete protection in mice against a deadly variant of the virus that causes bird flu. It focuses on the H5N1 variant known as 2.3.4.4b, which has caused widespread outbreaks in wild birds and poultry.
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Dr. Sabine Ehrt named Chair of the Department of Microbiology and Immunology at Weill Cornell Medicine
Dr. Sabine Ehrt, an internationally renowned leader in tuberculosis research, has been appointed chair of the Department of Microbiology and Immunology at Weill Cornell Medicine.
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Experts stress importance of vaccination amidst measles outbreaks
Pediatric infectious diseases experts stress the importance of vaccination against measles, one of the most contagious viruses, which is once more spreading in the United States.
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Investing in COVID-19 vaccination more than paid off for U.S., study finds
The US national Covid-19 vaccine strategy more than paid for itself after just one year, according to a new study. Because the vaccines reduced how many people developed serious illness or died, the nation saved more money than it spent.
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COVID-19 vaccination induces long-lasting antibody B-cell responses
A research study revealed that memory B cells maintain long-lasting and stable responses prior to mRNA vaccinations for COVID-19, but updated vaccines targeting new variants could boost immunity.
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Viral ‘backbone’ underlies variation in rotavirus vaccine effectiveness
A new study has shown that full-genome differences between rotavirus strains influence vaccine effectiveness, highlighting the need for a broader approach to vaccine design.
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Scientists develop nasal spray H5N1 avian influenza vaccine
Scientists have pioneered an influenza virus vector-based nasal spray vaccine platform and developed a nasal spray H5N1 avian influenza vaccine.
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New research boosts future whooping cough vaccines
By blocking the pertussis toxin epitopes with new found antibodies, researchers improved the pertussis vaccines to provide stronger, long-lasting immunity for infected and high-risk infants.
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Alternative approach to Lyme disease vaccine development shows promise in pre-clinical models
An international research team finds genetically engineered Lyme bacterial proteins could offer long-standing protection against infection while requiring fewer vaccinations.
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The beginning of the end: Setting a global target for rubella eradication
Scientists discuss the 2024 World Health Organization’s (WHO) recommendation for universal introduction of rubella-containing vaccines (RCVs) into childhood vaccination programs in all countries – particularly in the remaining 19 countries that have yet to do so.
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MOPEVACLAS vaccine candidate for Lassa fever enters clinical trials
After more than 20 years of research on arenaviruses, researchers have developed an original vaccine platform known as MOPEVAC. A Phase Ia clinical trial is set to begin for the platform’s first vaccine candidate, which targets Lassa fever, a hemorrhagic fever responsible for thousands of deaths worldwide each year.
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mRNA-based COVID-19 vaccines train the ‘long-term memory’ of the innate immune system
A study showed that vaccination of multiple mRNA-based COVID-19 vaccines could induce persistent epigenetic changes in innate immune cells, leading to long-term immune responses for SARS-CoV-2 and other pathogens.
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‘It’s a shot, not a vaccine like MMR’: New skepticism prompts call for action
This ‘vaccine is not a vaccine’ is a new, previously unreported type of vaccine-specific scepticism, and it arose only during the COVID-19 pandemic. However, it might, according to the researchers, also apply to the flu vaccine.
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How Zika virus knocks out our immune defenses
Scientists have made striking discoveries regarding the different infection mechanisms of Zika and dengue virus of the same viral family. These understandings pave the way for vaccine development to combat flaviviruses with similarities.
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Measles elimination versus eradication: The difference explained
As of March 13, the CDC has confirmed 301 cases of measles as well as the death of a child in Texas. Amira Roess, an epidemiologist and professor of global health, clarifies the benefits of vaccinating children and adolescents against measles.
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Newer hepatitis B vaccine shows promise as booster for health care workers
A new study compares the effectiveness of Heplisav-B, a new hepatitis vaccine, vs. standard hepatitis B vaccines as a booster in previously vaccinated individuals.
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‘Low-sugar’ vaccine can provide broad immunity against coronavirus variants
A universal vaccine for coronaviruses removes sugar molecules from an area of a coronavirus spike protein that rarely mutates and creates effective and plentiful antibodies to inactivate the virus.
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H5N1 influenza viral lineages beginning to evade human immunological defenses
A new computer modelling approach predicts the protein-antibody interactions of the potentially pandemic-causing H5N1 avian influenza virus lineage. It helps to understand the viral evolution to ensure high vaccine efficacy.
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Study yields new data on Mpox vaccine effectiveness in people with HIV
A new study has found that a single dose of the Imvanex vaccine provides protection against Mpox with 84% effectiveness. For people with HIV, however, a single dose of the vaccine fails to offer sufficient protection. All at-risk groups, especially people with HIV, should receive the second dose of the vaccine as recommended.
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Lead science organizations affirm vaccine safety amid rising misinformation and declining trust
A unified statement, issued by a coalition of leading scientific and medical organizations, addresses the rise in vaccine misinformation and a decline in trust of science, amidst the outbreaks of preventible infectious diseases. It reassures the current concerns on vaccine safety and emphasizes the importance of vaccinations in public health.