All University of Pennsylvania articles
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NewsThe Wistar Institute wins $15M+ NIH investment to advance HIV cure research strategies
The Wistar Institute has announced the National Institutes of Health (NIH) has awarded two major grants totaling more than $15M to Luis J. Montaner, D.V.M., D.Phil., director of Wistar’s HIV Cure and Viral Diseases Center.
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NewsGene-editing tool can unearth new cancer treatments from fungi
Engineers have developed a gene-editing tool built specifically for fungi, unlocking a hidden library of molecules—including some with early anti-cancer promise—from one of biology’s most overlooked kingdoms.
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NewsAI reveals unexpected source of antibiotic candidates in prion proteins
Prion and prion-like proteins may hide short peptides, named “prionins,” that can kill bacteria, suggesting proteins best known for their role in neurodegeneration may contain molecular features linked to immune defense, according to new research.
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NewsTesting AI against public health’s existing tools
A new study found that AI chatbots made vaccine-hesitant parents more likely to say they would vaccinate their children against HPV, but did not outperform materials from government health agencies, whose effects also lasted longer.
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NewsResearcher studying probiotics to fight acid reflux and esophageal cancer
Patients with acid reflux, which occurs when stomach acid pushes up into the esophagus, know the symptoms all too well: heartburn, belching, chest pain and trouble swallowing. Acid reflux also increases the risk of esophageal cancer, but researchers are investigating how a simple probiotic could treat and prevent both conditions.
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NewsSurvey highlights persistent uncertainty on STI vaccines
A nationally representative survey of empaneled adults finds that while most Americans understand how STIs spread, there are significant gaps in public knowledge about which infections can be prevented through vaccination.
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NewsTraditional dengue alerts are missing the mark as Vietnam’s climate shifts—researchers propose a one health solution
For decades, Vietnam’s dengue surveillance relied on a straightforward logic: when cases exceed the five-year average by a sufficient margin, sound the alarm. That logic is now breaking down.
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NewsPenn researchers create AI tool to speed antibiotic discovery
Researchers have developed a novel, AI-powered method for turning promising but imperfect antibiotic candidates into more potent ones. ApexGO starts with a small number of imperfect candidates and improves them step by step, using a predictive algorithm to evaluate each modification and guide the next.
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NewsHerpes virus fluidizes cell nuclei to multiply faster
A new study finds that herpes simplex virus uses a protein called infected cell protein 4 (ICP4) to make the human nucleus more fluid-like, which in turn makes it easier for the virus to replicate itself. Blocking the ability of ICP4 to fluidize the nuclear compartment caused a drop in viral copy production.
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NewsUS study finds declining perception of safety of COVID-19, flu, and MMR vaccines
A sizable majority of Americans think the three vaccines that combat potentially deadly illnesses flu, Covid-19 and measles are safe to take, although perceptions of the safety of all three vaccines showed a statistically significant drop over the past three years.
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NewsResearchers identify strategies for preventing the most infectious strains of S. aureus in the NICU
A new study has identified which strains of Staphylococcus aureus – commonly known as staph – are commonly transmitted in neonatal intensive care units and which specific strains are most likely to cause invasive and serious infections.
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News‘Nudging’ both patients and providers boosts flu vaccine numbers
Patients were 28 per cent more likely to get a flu shot when they got a text message reminder and their primary care provider already had an order for the shot waiting, new research showed.
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NewsMost would recommend RSV immunizations for older and pregnant people
A US survey found an increase in awareness of immunizations that are available for RSV. The survey of 1,637 U.S. adults also found that about 6 in 10 respondents would recommend the vaccine or antibody injections to the groups recommended by the CDC, an increase from past years.
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NewsResearcher reveals secrets of bacteria that can swim upstream
Rather than washing pathogens away, strong fluid currents act as “guide rails” that align bacteria and accelerate their upstream migration. They discovered that this creates a “two-way invasion” where pioneer cells reach the source within minutes, seeding colonies that spread threefold faster than in still water.
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NewsAs US measles cases rise, views of MMR vaccine safety and effectiveness – and willingness to recommend it – drop
As U.S. measles cases rise, a new nationally representative panel survey finds a small but significant drop in the proportion of the public that would recommend that someone in their household get the MMR vaccine, which protects against measles, mumps, and rubella.
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NewsWild birds are driving the current U.S. bird flu outbreak
Researchers traced the introduction and spread of highly pathogenic H5N1 viruses during the first 18 months in North America using genomic sequencing and migratory flyway analysis, discovering that the viruses were spread primarily by wild migrating birds.
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NewsMissing links for rabies in Peru highlights global threats of health inequity
Researchers found that efforts to track dog-related rabies in poorer areas of Peru’s second largest city were lacking even though more dogs were found to have the disease there than in wealthier neighborhoods.
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NewsDespite increase in U.S. cases, worry about West Nile virus remains low
Despite this season’s growing number of cases, relatively few Americans worry about becoming infected by West Nile or by dengue fever, another mosquito-borne illness, according to a survey of nearly 1,700 U.S. adults.
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NewsAI uncovers new antibiotics in ancient microbes
Researchers used artificial intelligence to identify previously unknown compounds in Archaea that could fuel the development of next-generation antibiotics.
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NewsMirror molecules deliver a one-two punch to superbugs to fight infections
Researchers have created mirror-image molecules that both kill pathogens outright and rally the immune system—an advance aimed at the growing crisis of antimicrobial resistance.