All University of California, Irvine articles
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NewsScientists fight drug-resistant parasites with nature-inspired drugs
As parasites become increasingly resistant to existing drugs, researchers are working to develop a new generation of treatments for two serious infectious diseases: malaria and babesiosis.
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NewsResearcher secures nearly $4 million NIH grant to advance therapeutic vaccine to help end genital herpes
University of California, Irvine immunologist Lbachir BenMohamed has been awarded a $3.93 million National Institutes of Health grant to develop and test a novel therapeutic vaccine designed to prevent recurrent genital herpes.
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NewsStudy identifies serious infection risks linked to targeted cancer therapies
A major real-world study has found serious blood-related side effects associated with antibody-drug conjugates, an increasingly important class of targeted cancer therapies. Some ADCs were associated with substantial rates of severe neutropenia – dangerously low levels of infection-fighting white blood cells – and related complications.
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NewsGut microbiome serves as key driver for bacterial infection outcomes for fatty liver disease
Researchers found that metabolic dysfunction–associated steatotic liver disease dramatically worsens outcomes following infection with Vibrio vulnificus, a potentially life-threatening foodborne bacterium commonly associated with seafood consumption.
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NewsResearchers deploy yeast platform to turn urine into high-value bio-implant material
Researchers have engineered a yeast platform that converts human urine from wastewater into hydroxyapatite, a high-value, biocompatible substance for use in dental and bone implants, restoration of archaeological artifacts and other applications.
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NewsScientists invent new drug candidates to treat antibiotic-resistant bacteria
Researchers designed a new family of antibiotics that’s a variation of an existing drug called vancomycin, which is used as a last resort for extremely ill patients. The new version of vancomycin targets, bonds to and renders inactive two different parts of a molecule on the surfaces of pathogenic bacteria.
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NewsScientists engineer new enzyme to produce synthetic genetic material
Researchers have engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid. The ability to synthesize artificial chains of TNA advances the discovery of therapeutic options to treat cancer and other diseases.
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NewsCircadian disruption and gut microbiome changes linked to colorectal cancer progression
Research has revealed how disruption of the circadian clock, the body’s internal, 24-hour biological pacemaker, may accelerate the progression of colorectal cancer by affecting the gut microbiome and intestinal barrier function.
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NewsScientists design new drug to fight malaria
Scientists have designed a new drug against malaria and identified its mechanism of action. MED6-189 is effective against drug-sensitive and drug-resistant P. falciparum strains in vitro as well as in a humanized mouse model.
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NewsResearch team creates novel rabies viral vectors for neural circuit mapping
Scientists have created 20 new recombinant rabies viral vectors for neural circuit mapping that offer significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer’s disease brain neurons.
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NewsResearchers reveal how microbes return after a wildfire
A study suggests that dispersal - through air or rain, for example - plays a major role in microbial succession after a destructive fire.
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NewsSome hosts have an ‘evolutionary addiction’ to their microbiome
Microbes might not actually be helping their hosts; instead, microbe-free hosts might malfunction because they have evolved an addiction to their microbes, says one evolutionary ecologist.
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NewsIncreased droughts are disrupting carbon-capturing soil microbes
Soil health and future greenhouse gas levels could be impacted if soil microbes adapt to drought faster than plants do.