All Pseudomonas aeruginosa articles
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Study advances understanding of immune system’s crucial role in phage therapy
Scientists have assessed the effectiveness of phage therapy in treating pneumonia. What they discovered about the mechanisms behind phage therapy could inform treatments in clinical settings to help patients facing similarly stubborn infections.
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New research reveals how bacteria export the building blocks of biofilms
Chemists examined how the polysaccharide “Pel” – a central component of many biofilms – is exported out of the cell by the pathogen P. aeruginosa and describe the structure of the so-called PelBC export complex, which represents the last station in the cell before “Pel” is released.
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Gifts from the sea: Molecules derived from coral may help fight harmful bacteria
Pus, strep throat, and even tuberculosis—most infectious diseases are characterized by a cluster of pathogenic bacteria that can be stubborn and resistant to antibiotics. Researchers have found another method to combat these bacteria using naturally sourced molecules found in corals.
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New source of natural antibiotics hidden within our own proteins identified
A team of scientists has identified a new type of antimicrobial peptides (AMPs) found in human proteins that are capable of selectively eliminating multidrug-resistant bacteria, particularly of the gram-negative type, responsible for serious hospital acquired infections.
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Bacteria hitch a ride on yeast puddles to zoom around
Researchers found that bacteria can speed up by using the fluid pockets shaped by neighboring yeast cells. These microscopic moisture trails allow bacteria to swim farther and spread faster—revealing a new way for microbes to travel through soil, plants, and the human body.
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Two-step method to prevent biofilm regrowth is a SLAM dunk
A new study reports a novel, two-step method to effectively dismantle bacterial biofilms and prevent regrowth.
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Blood eosinophil count is associated with Pseudomonas aeruginosa infection but not the efficacy of inhaled tobramycin
A study has demonstrated that blood eosinophil counts (BECs) correlate with the disease severity, lung function, exacerbations in bronchiectasis, a chronic airway suppurative disease.
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Study probes why patients with mitochondrial disease are more susceptible to infections
A new study shows that damaged mitochondria put the immune system in a constant state of alert, leading to dangerous overreactions when patients with rare mitochondrial diseases encounter bacteria.
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Scientists evaluate in-vitro activity of ceftazidime-avibactam against carbapenem-resistant gram-negative bacteria
Scientists explored the in-vitro activity of ceftazidime-avibactam (CAZ-AVI) in clinical isolates of carbapenem-resistant gram-negative bacteria collected at the outpatient, emergency, and inpatient departments of the Indus Hospital, Karachi.
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The first case of phage therapy for biliary tract infection caused by superbugs
A new study reports the first clinical application case of personalized phage therapy for biliary tract infection.
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Hidden virus harboured by fruit flies may influence experimental accuracy
A new study suggests the presence of Nora virus in laboratory strains of Drosophila fruit flies influences their resilience to stress and bacterial infection and can confound experimental studies of ageing.
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A high-fat diet may impair response to infection
A new study in The Journal of Immunology reveals how a high-fat diet may impair the immune system’s ability to respond to infection by impacting the function of neutrophils, one of the first immune cells to respond to bacteria or viruses. The study demonstrated that male mice fed a high-fat ...
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Damaged but not defeated: Bacteria use nano-spearguns to retaliate against attacks
Scientists used state-of-the-art microscopy technology to mimic a nano-speargun, the type VII secretion system, used as a bacterial pinpoint counterattack tactic in response to cell envelope damage against rival bacteria.
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Study uncovers the core principles of low-resistance antibiotics
Researchers have demonstrated that a dual-target approach, combining membrane disruption with an additional critical cellular pathway, significantly prevents the development of resistance in bacteria.
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Superbugs in our food: a new hope for tackling drug resistance
Researchers highlight the potential of quorum sensing inhibitors (QSIs) as a novel approach to tackle Pseudomonas aeruginosa. The study explores the mechanisms of action of various QSIs and potential applications in food safety and healthcare.
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Dangerous bacteria lurk in hospital sink drains, despite rigorous cleaning
Even in modern hospitals, drains can serve as reservoirs for known and novel pathogens, according to a new study.
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Delicate nanoflower is deadly to bacteria
A carnation-like nanostructure could someday be used in bandages to promote wound healing. Researchers report that laboratory tests of their nanoflower-coated dressings demonstrate antibiotic, anti-inflammatory and biocompatible properties.
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Papers outline 4 advances for inactivating infectious viruses and bacteria
Four papers provide insights into novel antiviral compounds and methods to inactivate infectious viral particles and bacteria.
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Researchers identify genetic ‘fingerprint’ to predict drug resistance in bacteria
To avoid antibiotic overuse and allow precise bacterial infection treatment, particularly against bacteria with multidrug resistance, a diagnostic tool was developed that identifies the pattern of DNA repair deficiencies acting as the bacterial antibiotic resistance ‘fingerprint’.
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CARB-X funds Rhode Island Hospital to assess feasibility of direct from blood detection of bacterial pneumonia
Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) will award Rhode Island Hospital at Brown University Health US$1M to demonstrate proof-of-concept of a polymerase chain reaction (PCR) approach informed by RNA sequencing to detect bacterial pneumonia directly from whole blood.