All Proteomics & Enzymology articles – Page 2
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NewsMarine algae use massive enzymes of unprecedented size to biosynthesize fish-killing toxins
Marine algae Prymnesium parvum use massive enzymes dubbed PKZILLAs – some of the largest proteins ever to be identified in nature – to make large and complex prymnesin neurotoxins responsible for mass fish kills during harmful algal blooms worldwide.
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NewsScientists get to the bottom of COVID’s worst pediatric complication
Scientists investigating multisystem inflammatory syndrome in children (MIS-C) found their immune systems had latched onto a part of the coronavirus that closely resembles a protein found in their bodies, launching an attack on their own tissues.
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NewsEnzyme discovery could lead to anti-bacterial pesticides targeting plant disease
Researchers investigating Xanthomonas plant pathogens have identified XccOpgD, a glycoside hydrolase (GH186) that plays a pivotal role in the biosynthesis of CβG16α, which suppresses essential plant defense mechanisms.
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NewsStudy identifies protein that affects health of gut microbiota and response to bacterial infection
A new study shows how the presence of a specific protein called IL-22BP affects the composition of the gut microbiota and the body’s response to bacterial infection.
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NewsPhage-derived enzyme targets biofilms to mitigate acute graft-versus-host disease
Scientists investigating acute graft-versus-host disease probe gut microbiome to detect presence of a bacteriophage-derived enzyme known as endolysin, exhibiting potent antibacterial activity specifically targeting E. faecalis.
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NewsScientists isolate amylase enzyme produced by indigenous bacteria from sugar factory waste
Experts in wastewater processing and treatment have isolated amylase-producing bacteria from the liquid waste of sugar local factories and optimized the production of the amylase enzyme.
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NewsDegradation of cell wall key in the spread of resistance
A new study shows how an enzyme breaks down the bacteria’s protective outer layer, the cell wall, and thus facilitates the transfer of genes for resistance to antibiotics.
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NewsWater-soluble version of bacterial enzyme may help researchers develop new antibiotics
Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics.
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NewsScientists unveil hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression
In liver cells under oxidative stress, HBV core protein (HBc) perturbs mitochondrial dynamics and prevents cellular recycling of damaged mitochondria, thereby driving liver disease progression, a new study finds.
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NewsNew, modified CRISPR protein can fit inside virus used for gene therapy
Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells. Hongjian Wang and colleagues at Wuhan University, China, present these findings May 23rd in the ...
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NewsResearchers may have come up with second chance for antibiotic agent
A new study focuses on the protein peptide deformylase (PDF), which is involved in protein maturation processes in bacterial cells. While the original drug candidate had to be discarded, modification of the molecule could offer a second chance.
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NewsBioengineered enzyme creates natural vanillin from plants in one step
Researchers have developed an enzyme which can convert ferulic acid from plant waste into vanillin – the classic vanilla flavored compound.
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NewsEnzyme that reproduces Meinwald reaction offers hope as bionanomachine for green chemistry
Researchers have for the first time precisely characterised the enzyme styrene oxide isomerase, which can be used to produce valuable chemicals and drug precursors in an environmentally friendly manner.
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NewsResearchers may have found an Achilles heel for Hepatitis B
Researchers have revealed never-before-seen mechanisms that may lead to new therapeutic approaches for HBV.
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NewsTransfected SARS-CoV-2 spike DNA suppresses cancer cell response to chemotherapy
Researchers have examined the interaction between SARS-CoV-2 spike, p53 and MDM2 (E3 ligase, which mediates p53 degradation) in cancer cells using an immunoprecipitation assay.
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NewsDiscovery of bacterial proteins that induce asexual reproduction in insects
From microbes in the human gut to symbiotic algae in coral reefs, research in recent decades has increasingly revealed the pivotal roles that microorganisms (or microbial species) play in shaping the biology of host organisms and of broader ecosystems. For example, some endosymbionts—microbes that live within the cells of a ...
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NewsResearchers uncover key biomolecule involved in whooping cough infection
Researchers have identified a new complex-carbohydrate biomolecule, or glycan, that plays a key role in the nasal colonization of the Bordetella bacteria responsible for whooping cough.
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NewsResearch uncovers a new path to drug diversity
By exploring protein evolution, scientists have found new “fusion sites” that enable faster and more targeted drug development.
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NewsMembrane-producing enzyme offers promising target
The enzyme LpxC, which catalyzes the first irreversible step in the biosynthesis of the outer membrane of Gram-negative bacteria, is a highly promising target for the development of antibiotics.
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NewsMutation linked to neurological disorders delivers double-pronged attack at cellular level
A mutation linked to neurological disorders knocks out not just one protein involved in translating the genetic code, but the entire cellular translation machinery. That’s the discovery of a team from the University of Maryland who were investigating how editing defects in threonyl-tRNA synthetase (ThrRS) work at ...
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