All Plasmodium falciparum articles
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NewsStudy provides first evidence of African children with severe malaria experiencing partial resistance to world’s most powerful malaria drug
A new study from Uganda provides the first evidence to date that resistance to a lifesaving malaria drug may be emerging in the group of patients that accounts for most of the world’s malaria deaths: young African children suffering from serious infections.
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NewsNoninvasive malaria test could be global game changer
Researchers present a new noninvasive test that could dramatically alter the global malaria testing landscape by providing reliable, safe, and sensitive testing to low- and middle-income countries.
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NewsScientists design new drug to fight malaria
Scientists have designed a new drug against malaria and identified its mechanism of action. MED6-189 is effective against drug-sensitive and drug-resistant P. falciparum strains in vitro as well as in a humanized mouse model.
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NewsFirst-of-its-kind vaccine expands malaria protection for pregnant women
For the first time, immunization with a malaria vaccine has been shown to protect mothers from malaria during pregnancy and to protect for two transmission seasons without booster doses of vaccine.
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NewsNew agent effective against drug-resistant malaria parasites
Scientists have developed a promising new antimalarial agent, DIF-1(+3), which is a derivative of Dictyostelium differentiation-inducing factor-1 (DIF-1).
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NewsUrgent action needed to combat rising antimalarial resistance in Africa
Urgent action is needed to prevent a surge in malaria-related sickness and death in eastern Africa, scientists say.
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NewsLow birth weight linked to placental malaria in first-time mothers
A new study aimed to determine the prevalence of placental malaria infection, risk factors, types of Plasmodium causing malaria during pregnancy, and its relationship with neonatal birth weight among primigravidae.
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NewsGenome research reveals the global march of malaria
Researchers have reconstructed ancient Plasmodium genome-wide data from 36 malaria-infected individuals spanning 5,500 years of human history on five continents, reconstructing the worldwide spread of malaria and its historical impact.
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NewsBreakthrough research identifies mechanism behind drug resistance in malaria parasite
A new study has found that a cellular process called transfer Ribonucleic acid (tRNA) modification influences the malaria parasite’s ability to develop resistance to Artemisinin-based combination therapies.
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NewsDeeper understanding of malaria parasite sexual development unlocks opportunities to block disease spread
For the first time, the developmental stages of the deadliest human malaria parasite have been mapped in high resolution, allowing researchers to understand this ever-adapting adversary in more detail than previously possible.
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NewsMalaria may shorten leukocyte telomeres among sub-Saharan Africans
Researchers have uncovered a potential role of malaria in shortening length of telomeres in white blood cells, known as leukocytes, across sub-Saharan Africa.
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NewsExperimental NIH malaria monoclonal antibody protective in Malian children
One injected dose of an experimental malaria monoclonal antibody was 77% effective against malaria disease in children in Mali during the country’s six-month malaria season, according to the results of a mid-stage clinical trial.
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NewsClimate change linked surge in malaria transmission could be less than feared
Despite concerns about the potential impact of climate change on increasing malaria risk, there is still limited understanding of how temperature affects malaria transmission – until now.
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NewsStudy reveals impact of malaria interventions through routine sampling of pregnant women
Genomic analysis of the malaria parasite in pregnant women attending their first antenatal visit revealed reduced diversity in areas of southern Mozambique where elimination interventions were implemented.
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NewsMalaria parasite generates genetic diversity using evolutionary ‘copy-paste’ tactic
Plasmodium falciparum, a malaria parasite, uses gene conversion to produce genetic diversity in two surface protein genes targeted by the human immune system.
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NewsResearchers discover that blocking an essential nutrient inhibits malaria parasite growth
Researchers have found that by preventing the malaria parasite from scavenging fatty acids, a type of required nutrient, it can no longer grow.
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NewsStudy supports potential for injectable ‘chemical vaccine’ for malaria using atovaquone
Researchers demonstrate in mouse model that key mutation that renders malaria parasites resistant to atovaquone also makes them non-transmissible via mosquitoes.
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NewsMainstay malaria drug may be beginning to fail in the Horn of Africa
In eastern Africa, malaria parasites have developed resistance to artemisinins, the backbone of current treatment regimens, a development that could dramatically worsen malaria’s impact if partner drugs fail in the future.
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NewsTargeting malaria parasite’s IncRNAs could halt life cycle progression
A study into mechanisms that regulate gene expression through the different stages of Plasmodium falciparum’s lifecycle could open new avenues for therapeutic strategies aimed at stopping the parasite’s life cycle progression.
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CareersUncovering the secrets of the mummy
To his great surprise, microbiologist Frank Maixner found himself turning his scientific skills to mummy research. He reveals what the latest techniques are revealing about ancient humans, the history of malaria and the Medici family.
