All Pharmaceutical Microbiology articles – Page 7
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Nano-drugs hitching a ride on bacteria could help target hard-to-reach pancreatic cancer
Employing bacteria to infiltrate the dense matrix of collagen and other tissues surrounding pancreatic tumors and deliver drugs could aid treatment for pancreatic cancer.
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Orangutan treats wound with antimicrobial, pain-relieving plant
A Sumatran orangutan with a facial wound ate and repeatedly applied sap from a plant with anti-inflammatory and pain-relieving properties commonly used in traditional medicine. He also covered the entire wound with the green plant mesh.
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Women need better treatments for bacterial vaginosis: call
Researchers at the University of Maryland School of Medicine are calling for robust studies for a treatment already used in Europe.
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Antimicrobial peptide from cows delivers way to kill hypervirulent bacteria
An antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae.
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Pioneering oral fungal infection treatment shows promise in preclinical trials
A novel oral amphotericin B (MAT2203) developed for treatment of invasive mucormycosis (IM) and other deadly invasive fungal infections, has demonstrated encouraging results in a series of preclinical studies.
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Study details a common bacterial defense against viral infection
One of the many secrets to bacteria’s success is their ability to defend themselves from viruses, called phages, that infect bacteria and use their cellular machinery to make copies of themselves. Source: Mogana Das Murtey and Patchamuthu Ramasamy Bacillus cereus, SEM image Technological advances have enabled recent ...
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Experts developing immune-enhancing therapies to target tuberculosis
Experts are working on novel immune-enhancing therapies called host-directed therapies to use the body’s own immune system to target tuberculosis, with hopes that they could tackle even the drug-resistant forms of the disease.
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Synthetic droplets cause a stir in the primordial soup
A synthetic droplet may give researchers clues on how the simplest forms of life on the planet could navigate their surroundings.
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Paclitaxel-induced immune dysfunction and activation of transcription factor AP-1 facilitate Hepatitis B virus replication
A study finds that Paclitaxel treatment directly promotes HBV replication and transcription, leading to HBV reactivation in HBV stable expression cell models, HBV natural infection cell models, and HBV transgenic mouse models.
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Study finds artificial intelligence can develop treatments to prevent superbugs
Researchers developed an AI model that can determine the best combination and timeline to use when prescribing drugs to treat a bacterial infection, based solely on how quickly the bacteria grow given certain perturbations.
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Engineers muffle invading pathogens with a ‘molecular mask’
Researchers are developing a hydrogel therapy that acts as a first line of defense against viruses and other biological threats. The peptides that make up this gel prevent viruses such as SARS-CoV-2 from attaching to and entering cells.
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Promising patient-friendly oral drug against visceral leishmaniasis enters Phase II clinical trial in Ethiopia
The new molecule has the potential to revolutionize treatment for the deeply neglected and hard-to-treat disease, as the Eastern Africa region charts the way to its elimination.
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Rise seen in use of antibiotics for conditions they can’t treat – including COVID-19
A five-year trend study shows a rebound in inappropriate use after an early-pandemic dip, and a need to tackle overuse in all patients during viral illness outbreaks.
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Birmingham Drug Discovery Hub creates an investment-ready ‘drug library’
A novel approach to drug discovery is enabling University of Birmingham researchers to overcome the ‘valley of death’, where projects fail due to the funding gap between original research and commercial investment.
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New class of antimicrobials discovered in soil bacteria
Scientists have mined Streptomyces for antibiotics for nearly a century, but the newly identified umbrella toxin escaped notice.
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Nanoparticle enhances antibacterial sonodynamic therapy for eradication of Pseudomonas aeruginosa biofilm
A novel ultrasound-launched targeted nanoparticle was developed to universally destroy biofilm, target bacteria, deliver antibiotics, and efficiently kill bacteria via ultrasonic cavitation and antibacterial sonodynamic therapy.
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Mechanism of action of the hepatitis B and D virus cell entry inhibitor bulevirtide deciphered
An international research team has succeeded in deciphering the molecular structure of bulevirtide in complex with the HBV/HDV receptor NTCP at the molecular level.
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Collaboration garners new support to tackle high-value tuberculosis targets
A groundbreaking collaboration will combat global health challenges in tuberculosis through innovative technology.
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Membrane-piercing drugs bring multidrug-resistant pathogens to their knees
A research team has introduced a method for the development of novel antibiotics to fight resistant pathogens. The drugs are based on protein building blocks with fluorous lipid chains.
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A combination of approved drugs enhances the delivery of anti-bacterial medications to treat tuberculosis
Scientists repurposed approved drugs that they originally tested to normalize blood vessels surrounding tumors to improve drug delivery to cancer cells.