All Pharmaceutical Microbiology articles – Page 16
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News
Versatile vaccine candidate fights measles, mumps and Covid
Altered measles and mumps viruses could be used as a platform to create a trivalent COVID-19 vaccine that triggers immunity to multiple variant strains of the SARS-CoV-2 virus, new research in animals suggests. The study builds upon previous studies that involved inserting a highly stable segment of ...
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SRI spins off AI-powered drug discovery platform Synfini, Inc
SRI International has announced it is spinning off Synfini, a biosciences platform that accelerates the process by which pharmaceutical and other companies can design, synthesize, and bring to market molecules for drug development.
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Antibiotics can help some bacteria survive for longer
Scientists have found a surprising effect of some antibiotics on certain bacteria – that the drugs can sometimes benefit bacteria, helping them live longer.
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Researchers pioneer safe chemotherapy methods for treating bacterial infections
Antibiotic resistant bacteria are a threat to human lives, and yet the development of new drugs to treat bacterial infections is slow. A group of proven drugs used in cancer treatment for decades could possibly be the solution. A new class of antibiotics is now being developed by researchers at ...
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Antiviral drug linked to SARS-CoV-2 mutations
Researchers have uncovered a link between an antiviral drug for COVID-19 infections called molnupiravir and a pattern of mutations in the SARS-CoV-2 virus.
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Fast-track strain engineering for speedy biomanufacturing
The time and money required to engineer microbes to produce vital medicines and chemicals can be dramatically reduced with a new model-based method.
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Blood cancer drug shows promise in killing ‘silent’ HIV cells
An existing blood cancer drug has shown promise in killing ‘silent’ HIV cells and delaying reinfections – a significant pre-clinical discovery that could lead to a future cure for the disease.
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Newly engineered versions of bacterial enzyme reveal how antibiotics could be more potent
Researchers have generated the full inventory of mutations in the bacterial species Escherichia coli where the antibiotic rifampicin attaches to and disables an essential bacterial enzyme known as RNA polymerase (RNAP).
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Research uncovers possible monoclonal antibody treatment for Lassa fever
New research potentially points to an effective treatment for Lassa fever, a dangerous, often fatal disease common to much of West Africa but considered a major threat to global health.
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Cargo system inhibits E.coli biofilms with a fraction of the antibiotic dose
Scientists have designed a bacteria-targeted cargo system that is capable of inhibiting a quinolone resistant Escherichia coli biofilm using much lower levels of antibiotic. The researchers, from Koç University School of Medicine in collaboration with College of Science, Department of Chemistry, encapsulated the antibiotic ciprofloxacin into superparamagnetic iron oxide nanoparticles ...
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Researchers decode new antibiotic clovibactin
Researchers have discovered and deciphered the mode of action of a new antibiotic, clovibactin, which is derived from a soil bacterium.
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Tests of new antifungal therapy for fungal meningitis are successful
Researchers have successfully tested a new oral formulation of the antifungal medication amphotericin among people who had HIV and cryptococcal meningitis - a common fungal infection around the brain.
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Careers
I was transformed into a cartoon scientist honey bee!
Professor Les Baillie of Cardiff University has had a few unique experiences as a microbiologist, but becoming one of the stars of Betsy and Bertie Save The Bees is one that earned particular kudos from his granddaughter.
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Molnupiravir dose of human effect size-equivalent blocks Covid transmission in ferrets
Two oral drugs provide equivalent therapeutic benefit in preventing severe COVID-19 in animal models, but only molnupiravir efficiently blocked SARS-CoV-2 transmission when administered at a human effect size-equivalent dose.
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Monoclonal antibody shows promise for treating chronic hepatitis B and D infections
In a preclinical study, the potential of an engineered investigational human monoclonal antibody for the treatment of chronic hepatitis B and hepatitis D has been demonstrated.
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Changes in gut microbiome alters rewarding effects of cocaine and cravings
Scientists have provided the first evidence that changes in the gut microbiome have significant effects on cocaine use and cravings after withdrawal.
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New HIV drug formulation could improve treatment outcomes for children worldwide
Researchers have confirmed the dosing, safety and effectiveness of a drug formulation designed for treating children with human immunodeficiency virus (HIV).
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Researchers discover method to overcome antimicrobial resistance
Scientists have found a new class of molecules that inhibit the efflux pump of a bacterial cell.
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Scientists develop new solid-state storage method for biological materials
Scientists have developed a novel method for storing biological materials such as RNA and proteins in a solid-state, physically resembling a pill or a tablet, which dissolves in water for on-demand use.
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Researchers uncover novel bacterial communication system to combat AMR
Using a sophisticated mass spectrometry technology developed at SMART and MIT, researchers have discovered that the enzyme RlmN is a stress sensor for reactive oxygen species (ROS) – highly reactive molecules which can cause damage to bacteria. Source: SMART AMR (L to R) SMART researchers Dr Cui Liang, ...