All National University of Singapore articles
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Multi-omics strategy reveals how insect parasite fungus ameliorates sepsis-associated acute kidney injury
Scientists have found that Cordyceps sinensis significantly ameliorates renal injury and inflammation in sepsis-associated acute kidney injury (S-AKI) by regulating mitochondrial energy metabolism and macrophage polarization.
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Researchers discover new Candida auris – a possible global public health threat
Researchers have discovered a new clade (or type) of Candida auris, bringing the number of clades known globally to a total of six.
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$14.8 million grant supports Illinois-Singapore partnership on precision fermentation for food
The team has received a five-year, $14.8 million-dollar grant to develop the Centre for Precision Fermentation and Sustainability (PreFerS), focusing on enhancing the reliable, cost-effective production of safe, nutritious, and appetizing foods.
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Vaccine approach offers promise to induce longer-lasting protective immunity against COVID-19
A scientific team has engineered a COVID-19 vaccine that induced – in pre-clinical models – very long-lasting, protective immunity against SARS-CoV-2 virus with a single-shot immunisation.
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Study identifies immunity threshold for protection against COVID-19 in children
Researchers have found rather than antibodies, other arms of the immune system – T cells and memory B cells – provide durable protection against symptomatic SARS-CoV-2 infection in children.
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Breakthrough antibiotic shows promise against obstinate mycobacterial infections
Researchers assemble a new antibiotic candidate, COE-PNH2, offering a more effective therapeutic option against hard-to-treat mycobacterial lung diseases.
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Researchers develop molecules for a new class of antibiotics that can overcome drug resistant bacteria
A new class of antibiotics not only shows promise against a broad array of bacterial infections but can also evade the dreaded resistance that has been rendering our current generation of first-line antibiotics ineffective.
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Scientists construct a synthetic yeast genome
The yeast genome contains redesigned chromosome sequences that can shed light on the impact of genetic variations on individual traits and potentially be used to reveal the causes of genetic diseases
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Nano-sized cell particles are promising tool in treating infectious diseases
In a new study, extracellular vesicles were found to inhibit the viral infection of COVID-19 and potentially other infectious diseases.
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Researchers unlock power of genetic glycoengineering to advance vaccine tech
A novel glycoengineering platform is poised to revolutionise future production of vaccines and therapeutics to fight infectious diseases.
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Gut inflammation caused by substance secreted by microbe
A rare subtype of the world’s most common parasite, Blastocystis, has been found to produce a unique by-product of its metabolism, which can cause gut inflammation under normal gut conditions.
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Parasites of viruses drive superbug evolution
Researchers have discovered a previously unknown mechanism by which bacteria share their genetic material through virus parasites.
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Gene-editing technology eliminates EV-A71 RNA viruses
Scientists have developed a CRISPR-Cas13 therapeutic against EV-A71, the RNA virus that causes hand, foot, and mouth disease.
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Newly discovered antibodies can neutralize COVID-19 variants
Scientists have isolated potent neutralizing antibodies from a COVID-19 vaccinated SARS survivor that exhibited remarkable breadth against known sarbecoviruses.
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Natural molecule added to toothpaste may help prevent plaque and cavities
Scientists have discovered that 3,3′-Diindolylmethane (DIM), a naturally occurring molecule also known as bisindole, reduces the biofilms that produce plaque and cavities by 90% and is also found to have anti-carcinogenic properties.
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Heart drug peruvoside could prevent spread of up to 12 viruses
Peruvoside, a plant-based compound that is commonly used to treat heart failure, has been discovered to be able to prevent up to 12 medically important viruses, all originating from different virus families.
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Anti-microbial nanonets ease inflammation during sepsis
Pharmaceutical scientists have developed multi-functional synthetic peptide nanonets for relieving inflammation caused by bacterial infection. This is achieved by concurrent trapping of bacterial endotoxins and pro-inflammatory cytokines.