All Microbial Genomics articles
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New therapy may effectively control HIV in Uganda
Clinical trials showed an effective antiviral drug, known as lenacapavir, against HIV in Uganda, and has also been tested for drug resistance in different subtype strains.
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Scientists clarify relationships of earth tongues aka Geoglossomycetes
Researchers studied 34 samples of earth tongues from China, reconstructing the phylogenetic framework of Geoglossomycetes and introducing ten new species.
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New method ‘fishes’ for bacterial STI DNA, revealing how Chlamydia spreads and adapts
Scientists have developed a cutting-edge “target enrichment” technology for bacterial STIs. Using specially designed molecular probes, they “fished” for bacterial STI DNA from clinical samples, enabling high-resolution genome analysis.
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Symbiotic bacteria ride along with marine cells in ocean’s upper layer
Symbiotic bacteria often accompany single-celled protists in the ocean’s upper layer. Some of these symbionts, scientists have discovered, are close relatives of bacteria pathogenic to animals, including humans.
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Reemergence of dengue serotype 3 may increase severity of outbreaks of the disease in Brazil
From the genomic and epidemiological surveillance of the circulating dengue virus strains, a more severe dengue epidemic may occur in Brazil, due to the re-establishment of dengue virus serotype 3 (DENV-3) and persists alongside with the serotype 1 and 2 (DENV-1 and DENV-2).
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Scientists recode the genome for programmable synthetic proteins
Synthetic biologists were able to re-write the genetic code of an organism — a novel genomically recoded organism (GRO) with one stop codon — using a cellular platform that they developed enabling the production of new classes of synthetic proteins.
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Bat genome signposts new potential pathway to fight viruses with genomic characterization
A promising discovery has been made from a study that deciphers how bats are more resistant to viral infections than human using genome annotations of transposable elements in bats to pave a way for adapting the bats’ immunity against future viral outbreaks.
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New phage platform pinpoints viruses that can deliver a knockout blow for killer bacteria
An international group of microbial experts has launched a powerful and flexible free online genomic toolkit for more rapid development of phage therapy. They say it is capable of assessing if a phage is suitable for a targeted therapy in under 10 minutes.
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Gene found in rough Salmonella Infantis variant offers drug target for variety of pathogens
A new study identifies a gene in a rough Salmonella Infantis variant that could offer a target for developing effective vaccines and therapeutic strategies, not only for Salmonella but other Enterobacteriaceae as well.
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New tool can detect fast-spreading SARS-COV-2 variants before they take off
By analysing millions of viral genome sequences from around the world, a team of scientists has uncovered the specific mutations that give SARS-CoV-2 a ‘turbo boost’ in its ability to spread.
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Researchers identify genetic ‘fingerprint’ to predict drug resistance in bacteria
To avoid antibiotic overuse and allow precise bacterial infection treatment, particularly against bacteria with multidrug resistance, a diagnostic tool was developed that identifies the pattern of DNA repair deficiencies acting as the bacterial antibiotic resistance ‘fingerprint’.
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Final synthetic yeast chromosome unlocks new era in biotechnology
A team of researchers has successfully synthesised the very first yeast chromosome using specialised genome-editing technique that provides insights for synthetic biology and biomanufacturing fields.
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Decoding HIV genomic tactics in viral replication
Research on HIV-1 unravels the viral and host translational regulations during viral replications through the identification of RNA structures and previously unrecognized genetic elements - this could bring potential therapeutic interventions to counter the viral manipulations.
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Bacterial small noncoding RNA promotes gut colonization by regulating sialic acid metabolism
A novel 3′ UTR-derived small noncoding RNA was discovered to regulate metabolism of N-acetylneuraminic acid in Salmonella enterica pathogenesis.
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Study finds diversity of deadly bacteria different in Saudi Arabia compared with rest of world
The largest epidemiology study ever of multidrug resistant Klebsiella pneumoniae in Saudi hospitals reveals a unique health strategy is required for Saudi Arabia.
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Genome researchers unfurl protective mantle of influenza virus
The structure of the flu virus’s protective mantle and its interactions with its RNA have been described on an atomic scale by a research team for the first time.
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Historic outbreaks of coffee wilt disease linked to gene transfer from another fungus
The fungus that causes coffee wilt disease repeatedly took up segments of DNA from a related fungal pathogen, which contributed to successive outbreaks of the disease.
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How did human brains get so big? The answer could be in our gut
Microbes supporting the production of more metabolic energy could be key to the evolution of large brains, according to a study that shows gut microbes from different animal species shape variations in their biology.
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New tool enables a more complete and rapid decoding of the language of algal gene expression
A new method that research teams can use to measure and compare different forms of proteins and protein complexes helped reveal a previously unseen molecular signature of how algal genomes are controlled during the cell cycle.
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Single-cell genomics decodes bacteria genomes and uncovers new species
A team of researchers has developed a groundbreaking single-cell genome approach. This approach, which reads information from individual cells, offers a promising alternative to conventional metagenomics.