All Medical Microbiology articles
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A cocktail of drugs may work against a whole family of viruses
Enteroviruses cause everything from polio to meningitis. An effective treatment could help reduce the risk of this global health problem.
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New treatment for cryptococcal meningitis enters Phase II trial
Cryptococcal meningitis, the second-leading cause of HIV-related deaths, is expected to rise as access to care weakens and advanced HIV disease (previously called AIDS) increases.
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Bacterium promotes liver regeneration by increasing β-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals
Parabacteroides distasonis promotes liver regeneration by increasing BHB production and BHB-driven STAT3 signals, providing an argument for using P. distasonis or BHB as a potential strategy for promoting hepatic regeneration after PHx or transplantation.
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Study of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients
A study used five analytical methods to show that oral azvudine has a therapeutic effect in elderly COVID-19 patients aged over 60 years.
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Studies shows new class of antibiotic is effective in tackling MRSA
New research has shown a daily dose of epidermicin NI01 – an antibiotic compound developed by University of Plymouth spinout company Amprologix – is as effective at removing Methicillin-resistant Staphylococcus aureus (MRSA) as the current standard of care.
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Researchers reach poo-romising frontier in fecal microbiota transplantation
Recent research suggests that fecal microbiota transplantation could play a pivotal role in the eradication of Helicobacter pylori, either as a monotherapy or an adjunct to conventional treatments.
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Parasitic infection and treatment linked to cancer-related gene activity in the cervix
New research has revealed that Schistosoma haematobium, a parasitic infection affecting millions globally, can trigger cancer-related gene activity in the cervical lining, with changes becoming even more pronounced after treatment.
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Breaking the mold: a rare case of Exophiala jeanselmei pneumonia in a patient with interstitial lung disease
Scientists report the first case of Exophiala pneumonia in Pakistan, occurring in an immunocompetent, middle-aged female with interstitial lung disease.
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Investing in COVID-19 vaccination more than paid off for U.S., study finds
The US national Covid-19 vaccine strategy more than paid for itself after just one year, according to a new study. Because the vaccines reduced how many people developed serious illness or died, the nation saved more money than it spent.
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Breakthrough gene therapy offers hope for rare, deadly heart disease in young men
Researchers have designed a gene-therapy strategy that could transform the treatment of arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5), a rare and deadly heritable disease that particularly affects young men.
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Tackling the ‘silent pandemic’: breakthrough study puts first long COVID treatment on horizon
Researchers have shown a new drug compound can prevent long COVID symptoms in mice – a landmark finding that could lead to a future treatment for the debilitating condition.
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The first case of phage therapy for biliary tract infection caused by superbugs
A new study reports the first clinical application case of personalized phage therapy for biliary tract infection.
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Researchers discover way to predict treatment success for parasitic skin disease
Researchers have discovered a way to predict whether a patient suffering from cutaneous leishmaniasis will respond to the most common treatment, potentially saving patients from months of expensive, ineffective and toxic medication.
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Some gut bacteria could make certain drugs less effective
Researchers discovered that gut bacteria can metabolize oral administered drugs that target G protein-coupled receptor (GPCR) and potentially other chemicals and food compounds, leading to impacts on the effectiveness of medication to patients.
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Surgical fixation for infected sites in pyogenic spondylodiscitis inhibits bone destruction and promotes healing
Pyogenic spondylodiscitis is caused by bacterial infections of the spine and intervertebral discs. Researchers investigated how osterior fixation, in which the normal spine is fixed with pedicle screws and rods to stabilize the infected site, suppresses infection.
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The gut microbiota-metabolites-brain axis mediates social behavior dysfunction following anaesthesia
New research shows that the anaesthetic Sevoflurane (Sev) influences social functioning via the gut-brain axis, with microbiota-derived bile acids serving as critical mediators in this pathway.
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Evaluating DNA impurities in recombinant adeno-associated virus
A new study indicates that DNA impurities derived from plasmid and host cell DNA are encapsulated into recombinant adeno-associated virus (rAAV) capsids as single-stranded DNA.
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Antibody-based therapy is several steps closer to treat lethal mucormycosis
A new paper discusses the use of monoclonal antibodies to target a key fungal cell surface protein, CotH, which enables the Mucorales fungus to invade human cells and cause mucormycosis, which has high mortality rates in people with weakened immune systems.
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Selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide
A new study highlights a novel mechanism of action driven by polysulfides, presenting a promising alternative strategy for combating H. pylori infections.
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McMaster leads Canada’s first-ever guidelines for Post COVID-19 Condition
A team of experts from McMaster University has led the creation of Canada’s first-ever comprehensive guidelines for diagnosing, managing, preventing, and treating post COVID-19 condition (PCC), more commonly known as long COVID.