Latest News in WAAW – Page 27
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Single hepatitis E mutation renders sofosbuvir therapy ineffective
A single mutation of the hepatitis E virus has been shown to cause treatment with the hepatitis C drug sofosbuvir to become much less effective, according to a study that provides new insights for future drug development.
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Drugs targeting malaria in Mozambique are still effective
The drugs used to treat and prevent malaria in Mozambique are still effective, according to a genomic analysis of drug resistance markers in Plasmodium falciparum, carried out by the Barcelona Institute for Global Health (ISGlobal) and the Manhiça Health Research Center (CISM). Source: CDC/ Dr. Mae Mellvin Photomicrograph ...
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Drug-resistant fungi thriving in the most remote regions of Earth
New research has found that a disease-causing fungus — collected from one of the most remote regions in the world — is resistant to a common antifungal medicine used to treat infections.
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Bioactive glass doped with silver delivers longer-lasting antimicrobial wound protection
Researchers at the University of Birmingham have demonstrated that silver retains antimicrobial activity for longer when it is impregnated into ‘bioactive glass’, and shown for the first time how this promising combination delivers more long-lasting antimicrobial wound protection than conventional alternatives.
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Biotech spinoff PHIOGEN to tackle threat of antimicrobial resistance
A new biotech spin-off, PHIOGEN, has developed a world-first technology platform that mobilizes the natural power of bacteriophages to tackle critical and life-threatening infections.
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Treatment with enzyme inhibitor can help combat antimicrobial resistance
Researchers have shown that intravenous treatment with MK-3402, a metallo-beta-lactamase inhibitor, can be an effective strategy in fighting antimicrobial resistance.
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Scientists discover small RNA that regulates bacterial infection
Researchers have identified the major mechanism behind the transition between chronic and acute P. aeruginosa infections.
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Newborns worldwide dying from sepsis as antibiotics lose their bite
A global observational study involving more than 3,200 newborn babies suffering from sepsis in 11 countries has shown that many newborns are dying because the antibiotics used to treat sepsis are losing their effectiveness.
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Microbiome takes centre stage at keynote lecture
Dr Martin Blaser delivered the Ashford Memorial Lecture 2023, which commemorates the legacy of Dr. Bailey Kelly Ashford, who changed the infectious disease landscape of Puerto Rico in the early 20th century.
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Novel combination therapy counters antibiotic-resistant Mycobacterium infections
Researchers have discovered a novel therapy by combining two antibiotics, rifaximin and clarithromycin, to treat Mycobacterium abscessus, a non-tuberculous mycobacterium (NTM) that causes chronic lung-related infections.
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Biological clocks of people and malaria parasites tick in tune
Research could pave the way to new anti-malarials that work by ’jet-lagging’ the parasites that cause the disease.
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Fruit fly compound could lead to new antibiotics
Scientists have found that a peptide from fruit flies could lead to new antibiotics.
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Global response to antimicrobial resistance ‘insufficient’
Governments around the world must do more to tackle the growing threat of drug-resistant infections, new research suggests.
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Team founds AI-powered vaccine library to prevent future pandemics
A research project to develop novel antigen designs will focus on 10 known virus families to build the ‘vaccine library’, using the computer-based Rosetta platform.
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Previously unknown antibiotic resistance widespread among bacteria
A new study shows that bacteria in almost all environments carry resistance genes, with a risk of them spreading and aggravating the problem of bacterial infections that are untreatable with antibiotics.
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Workings of bacterial RNA riboswitch laid bare
Researchers have revealed, using a combination of biochemistry, structural biology and computational modeling, how a particular riboswitch regulates its own synthesis, offering a new target for antibiotics.
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Drugs pipeline rife with strategies to combat MRSA
A host of new antimicrobial strategies are in the development pipeline that could provide hope for healthcare sectors battling multi-drug resistant Staphylococcus aureus infections.
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Study uncovers how Leishmania parasite adapts so quickly to drugs
Scientists probing the parasite’s gene expression regulation during mRNA translation have discovered how it is able to preemptively and quickly adapt and respond to drug treatments.
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Staph mechanism for resistance to last resort drug is uncovered
New research has revealed the mechanism of transcriptional regulation via S-nitrosylation for resistance to last resort drug vancomycin in Staphylococcus aureus.
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Nanorobots seek and destroy fungal infections in the mouth
Researchers have developed a new way to rapidly and precisely eradicate fungal infections in the mouth by using nanorobots guided by magnets.