All Immunology articles – Page 9
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Dengue vaccine is effective and safe, reveals first global meta-analysis
The study, conducted by cross-referencing data from 19 scientific studies, involving over 20,000 individuals, shows an efficacy rate of over 50% in reducing disease cases, with lasting effects and a high safety profile.
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New two-step flu vaccine strategy shows promise in pig model
A new, two-step flu vaccination strategy that pairs intramuscular injection of a viral vectored flu vaccine with nasal spray administration of a novel attenuated live flu virus appears to be safe and effective in pigs.
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Do smells prime our gut to fight off infection?
A recent study shows that the nematode C. elegans reacts to the odor of pathogenic bacteria by preparing its intestinal cells to withstand a potential onslaught.
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Scientists get to the bottom of COVID’s worst pediatric complication
Scientists investigating multisystem inflammatory syndrome in children (MIS-C) found their immune systems had latched onto a part of the coronavirus that closely resembles a protein found in their bodies, launching an attack on their own tissues.
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Study explains why virus causing cold sores does not spread to devastating brain infection
Researchers have discovered a previously unknown defence mechanism in the body that is the reason why herpes infection causes a serious and potentially fatal brain inflammation in only one out of 250,000 cases.
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Researchers make breakthrough in bid to develop vaccines and drugs for neglected tropical disease
Scientists have developed a new, safe and effective way to infect volunteers with the parasite that causes leishmaniasis and measure the body’s immune response, bringing a vaccine for the neglected tropical disease a step closer.
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Mouse study reveals how fetal brain impacted when mother fights severe flu
A bad case of the flu during pregnancy can increase the risk for fetal neurodevelopmental disorders such as schizophrenia and autism spectrum disorder. But it’s not the virus itself doing the damage; it’s the mother’s immune response.
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Scientists uncover genes that contribute to severe COVID-19 susceptibility
Researchers confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to find evidence for a contribution of the gene in women.
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Prenatal Zika infection has long-term immune consequences in children, even without microcephaly
New findings challenge the current diagnostic criteria for congenital Zika syndrome, expanding the definition beyond skull or brain abnormalities.
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Study identifies unpredicted immune responses to adenoviral COVID vaccines
Researchers have identified unpredicted T-cell immune responses to the adenoviral (Oxford/AstraZeneca and Janssen) COVID-19 vaccines, but not to the mRNA vaccines.
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Study shows promise for a universal influenza vaccine
New research reveals a promising approach to developing a universal influenza vaccine — a so-called “one and done” vaccine that confers lifetime immunity against an evolving virus.
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Study identifies protein that helps COVID-19 virus evade immune system
Discovery of a new viral evasion mechanism, and of a monoclonal antibody that subverts it, is an advance in immunotherapy that offers the prospect of effective host-directed treatment to combat infections.
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Early life antibiotic increases risk of asthma: providing clues to a potential prevention adult asthma
Early exposure to antibiotics can trigger long term susceptibility to asthma, according to researchers who isolated a molecule produced by gut bacteria that in the future could potentially be trialed as a dietary supplement for children at risk of asthma.
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Respiratory bacteria ‘turns off’ immune system to survive
Researchers have identified how a common bacterium is able to manipulate the human immune system during respiratory infections and cause persistent illness.
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Hepatitis C leaves ‘scars’ in immune cells even after successful treatment
Researchers have discovered that traces of ‘epigenetic scars’ remain in regulatory T cells and exhibit sustained inflammatory properties long after the Hepatitis C virus is cleared from the body.
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Scientists discover how to improve vaccine responses to potentially deadly bacterium
Researchers have shown in an animal model that targeting a key suppressive immune molecule (IL-10) during the delivery of a vaccine improves the ability of the vaccine to protect against infection.
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Study backs RSV vaccine safety during pregnancy
Vaccinating mothers against respiratory syncytial virus (RSV) during late pregnancy to protect their newborns is not associated with an increased risk of preterm birth or other poor outcomes, according to a new study.
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Uncovering ‘Blockbuster T cells’ in the gut wins major prize
Kazuki Nagashima developed a method with which to zero in on individual gut bacterium’s impacts on T cells. His work showed that – contrary to what has been thought – some T cells in the gut can interact with multiple bacteria.
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Researchers reveals why recombinant BCG induces a stronger and longer-lasting response
Researchers are working on a more potent version of the BCG vaccine that protects against TB. While the conventional immunizer reduced infection by 90% in experiments with mice, the recombinant BCG increased protection rates to 99%.
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From ‘hit to vial’: Discovery and optimization of a promising vaccine adjuvant
Scientists identified a new and promising adjuvant, dubbed PVP-037 - in principle, this compound can be added to any vaccine to enhance its action.