All Immunology articles
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Staphylococcus aureus thwarts vaccines by turning on a protein that halts immune response
Approximately 30 clinical trials to date have failed to result in an effective human vaccine for Staphylococcus aureus but researchers have now identified a key reason for these failures, indicating that it may be possible to modify the vaccines to work in humans.
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A dial for tuning the immune system: Discovery sheds light on why COVID makes some sicker than others
A new study identifies an “immune system tuning dial,” which originated as a bug in the genetic code tens of millions of years ago. When this signaling goes awry and leads the body to under or overreact, people are more likely to develop severe or Long COVID.
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Global research uncovers critical weakness in malaria parasite
Scientists exploring how immunity develops against Plasmodium falciparum found that broadly reactive antibodies from various individuals consistently bound to the same site on a key virulence protein of the malaria parasite.
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Researchers uncover role of Cul3/Diap2/Dredd axis in mediating the host antimicrobial immune defense
Researchers combined a series of genetics, immunology and molecular biology approaches to confirm that Cul3 plays an essential role in the Drosophila antimicrobial immune defense.
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Researchers call for global discussion about possible risks from ‘mirror bacteria’
A group of researchers has published new findings on potential risks from the development of mirror bacteria — synthetic organisms in which all molecules have reversed chirality (i.e. are ‘mirrored’).
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Researchers uncover how bat-origin pathogenic viruses manipulate human cell death and inflammation
A new study offers insights into cell death regulation by viruses like SARS-CoV-2, and how bats and humans respond differently to tricks that such viruses use to manipulate the host’s defense.
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Updated Hep B vaccine more effective for people with HIV
A newer vaccine against hepatitis B virus was clearly superior to an older vaccine type in inducing a protective antibody response among people living with HIV who didn’t respond to prior vaccination, according to an international study.
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Study reveals early immune protection in the womb
Researchers have discovered that fetuses can manage their own immune responses to combat diseases and infections like Zika.
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Mouse gut fungus reveals secrets of symbiosis and allergy
A fungus discovered in the mouse stomach may hold a key to fungal evolution within the gastrointestinal tract, according to new research. The finding suggests that preclinical studies until now have overlooked a major influencer of mouse physiology.
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Researchers develop light-guided siRNA delivery system based on cyanobacteria
In a study published in Cell Reports Physical Science on Nov. 25, a research team led by Prof. Cai Lintao from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences reported its development of an innovative intelligent light-guided biohybrid system, the CTPA/siCSF1R system, to target tumor-associated ...
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Scientists implicate a novel cellular protein in hepatitis A infection
Viruses have thrived in humans for tens of thousands of years, evolving to take advantage of the machinery of cells to replicate and survive inside us. Some can slip past our defenses and invade without even causing symptoms. Source: Shirasaki et al. (2024) (Left) Liver cells infected with ...
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New mechanism to fund clinical studies addressing the impact of diet, nutrition, and microbiome on lupus
The unique IDEAL (Investigate Dietary Approaches for Lupus) Initiative will provide multi-disciplinary research teams the opportunity to conduct innovative and much-needed research of diet in lupus.
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Simple COVID-19 vaccine can be stored at room temperature and administered as a nasal spray
Researchers have developed an effective, inexpensive, and simple COVID-19 vaccine that can be stored at room temperature and administered as a nasal spray.
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Study uncovers key heart responses to viral infection
Researchers at the University of Virginia have made a significant discovery that could change how doctors treat viral infections of the heart. Source: UVA Engineering Kevin Janes, University of Virginia John Marshall Money Professor, Department of Biomedical Engineering and Department of Biochemistry & Molecular Genetics. The ...
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Probiotic delivers anticancer drug to the gut
Researchers have engineered a probiotic that delivers immunotherapy directly to the gut to shrink tumors in mice, offering a potentially promising oral drug for hard-to-reach cancers.
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Human antibodies could prevent the malaria parasite from causing life-threatening infections
Malaria, particularly in its severe forms, remains a global health and economic burden. It causes the deaths of more than 600,000 people every year – most of them African children under five. In a new study, published in the journal Nature, researchers from EMBL Barcelona, the University of Texas, the ...
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Women’s health company Freya Biosciences announces key $10.4m strategic investment
Freya Biosciences, a transatlantic biotech company specializing in women’s health, has announced a major strategic investment which will be used to develop microbial immunotherapies for the treatment of bacterial vaginosis.
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A new technology to isolate immunostimulatory members of the human gut microbiota
Scientists have developed a new technology to isolate a specific subset of gut bacteria that are recognized by IgA antibodies. These ‘IgA-coated’ bacteria are associated with an array of diseases and this proposed new technology has the potential to uncover the mechanisms behind these correlations.
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Zinc deficiency promotes Acinetobacter lung infection: study
Dietary zinc deficiency promotes lung infection by Acinetobacter baumannii bacteria — a leading cause of ventilator-associated pneumonia, according to a new study.
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New evidence links gut microbiome to chronic disease outcomes
A new review consolidates recent findings that demonstrate a causal role for the gut microbiome in the progression of multiple diseases, ranging from gastrointestinal conditions to immune-related and psychiatric disorders.