All HIV articles – Page 4
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Small protein plays big role in chronic HIV infection
Using a mouse model of neuroHIV, researchers studied the effects of interferon-β (IFNβ), a small protein involved in cell signaling and integral to the body’s natural defense mechanism against viral infections.
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New method developed to isolate HIV particles
Researchers have broken new ground for faster diagnosis of HIV, with the development of a new method for isolating particles.
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Case report shows mpox breakthrough infection in man who had received both vaccine doses
New research details the case of a man who had received two doses of the monkey pox vaccine in Autumn, 2022 yet experienced a ‘breakthrough’ mpox infection in January 2024.
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Implantable device delivers HIV antiviral with more potency than oral drugs
A study shows that a nanofluidic implant delivered an HIV drug that achieved more potency than other forms of drug administration (oral) and other HIV drugs.
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Researchers a step closer to a cure for HIV
A new study demonstrates that a patented therapeutic candidate, an HIV-virus-like-particle (HLP), is 100 times more effective than other candidate HIV cure therapeutics for people living with chronic HIV on combined antiretroviral therapy (cART).
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HIV in cell culture can be completely eliminated using CRISPR-Cas gene editing technology
New research demonstrates transport of new-gene editing technology to ‘cut out’ HIV DNA from infected cells; preliminary findings are “very encouraging”, but much work is needed to transform the technology into a cure for HIV.
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Drug candidate may ‘unmask’ latent HIV-infected cells, mark them for destruction
Scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.
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Researchers open new leads in anti-HIV drug development, using a compound found in nature
Researchers have successfully modified a naturally occurring chemical compound in the lab, resulting in advanced lead compounds with anti-HIV activity.
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Long-acting HIV treatment benefits adults with barriers to daily pill taking and adolescents with suppressed HIV
Long-acting, injectable antiretroviral therapy (ART) suppressed HIV replication better than oral ART in people who had previously experienced challenges taking daily oral regimens and was found safe in adolescents with HIV viral suppression.
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Children surpass a year of HIV remission after treatment pause
Four children have remained free of detectable HIV for more than one year after their antiretroviral therapy (ART) was paused to see if they could achieve HIV remission.
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Long-acting HIV treatment demonstrates efficacy in people with challenges taking daily medicine as prescribed
Long-acting antiretroviral therapy (ART) with cabotegravir and rilpivirine was superior in suppressing HIV replication compared to daily oral ART in people who had been unable to maintain viral suppression through an oral daily regimen, according to interim data from a randomized trial. Source: NIAID Colorized transmission electron micrograph ...
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Uptake of HIV prevention medication doubles with mix of digital health interventions
A combination of interventions of one-on-one telehealth coaching, peer support forums, and automated text messages more than doubled the use of the HIV prevention strategy, called PrEP, among younger, at-risk Americans.
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Droughts may trigger HIV transmission increase among women in rural sub-Saharan Africa
Droughts have the potential to increase the spread of HIV for women living in rural parts of Africa, researchers at the University of Bristol have found.
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PD-1-enhanced DNA vaccine achieves 6-year cART-free AIDS prevention and virologic control
Researchers have found that PD-1-enhanced DNA vaccination can induce sustained virus-specific CD8+ T cell immunity in an AIDS monkey model.
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Researchers are using RNA in a new approach to fight HIV
Scientists have developed a novel nanomedicine loaded with genetic material called small interfering RNAs (siRNA) to fight human immunodeficiency virus (HIV) using gene therapy.
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Research reveals how lenacapavir pushes HIV capsid to breaking point
Researchers have uncovered the details of how the novel drug lenacapavir works to stop the virus in its tracks. The molecular mechanisms that they uncovered could help to refine and design more effective anti-viral therapies.
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New trial highlights incremental progress towards a cure for HIV-1
A new clinical trial suggests that a combination of the drug vorinostat and immunotherapy can coax HIV-infected cells out of latency and attack them.
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Study reveals accelerated aging in women living with HIV
Women with HIV experience accelerated DNA aging, a phenomenon that can lead to poor physical function, according to a new study.
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Scientists spot an ultra-fast movement on surface of HIV virus
Investigators catch ultra-fast HIV docking mechanism in the act, giving them a new handle on the surface of the virus that could lead to broadly neutralizing antibodies for an AIDS vaccine.
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Simulations show how HIV sneaks into the nucleus of the cell
A new study has revealed how HIV squirms its way into the nucleus as it invades a cell.