All Early Career Research articles
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Barriers remain to peptide-based therapies - but there are answers, reveals study
Peptide-based therapies offer the potential to transform how we treat a range of conditions - but have yet to be adopted for widespread clinical use. A new review uncovers the barriers to adoption and identifies ways to overcome these limitations.
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Study of facial bacteria could lead to probiotics that promote healthy skin
Researchers have revealed the dynamics of interactions between two dominant skin bacterial species in more detail than previously possible, shedding light on when and how new bacterial strains emerge on the skin of the face.
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Bacteria deployed as living test tubes to study human gene mutations
Bioengineers have developed a new simple approach to rapidly check on human gene changes and also screen chemicals as potential drugs by turning everyday bacteria into living test tubes.
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New AI technique can uncover antiviral compounds using limited data
Artificial intelligence algorithms have been combined with traditional laboratory methods to uncover promising drug leads against human enterovirus 71 (EV71), the pathogen behind most cases of hand, foot and mouth disease.
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Cutting off parasite’s energy supply could help fight malaria
Once inside the body of an infected person, the malaria parasite relies on a process called glycolysis to produce energy and stay alive. Blocking the enzymes involved in this process could cut off the parasite’s primary energy source and kill it.
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Broader antibiotic use could change the course of cholera outbreaks, research suggests
Disease modeling research suggests that, for some cholera outbreaks, prescribing antibiotics more aggressively could slow or stop the spread of the disease and even reduce the likelihood of antibiotic resistance.
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Fungi dwelling on human skin may provide new antibiotics
Researchers have uncovered a molecule produced by yeast living on human skin that showed potent antimicrobial properties against a pathogen responsible for a half-million hospitalizations annually in the United States.
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Human protein HSF2 helps wake up sleeping cancer-linked viruses
A new study demonstrates the ability of the human protein HSF2 to remodel the viral DNA to enable the transition from dormant viral latency to active lytic reactivation.
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How math helps to protect crops from invasive disease
New research demonstrates how mathematical modeling can predict outbreaks of toxic fungi in Texas corn crops—offering a potential lifeline to farmers facing billions in harvest losses.
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BNT162b2 vaccine not only targets COVID-19 virus, but may also help control innate inflammation
New findings suggest the BNT162b2 vaccine may reduce the production of pro-inflammatory mediators to bacterial, fungal or viral infections by reprogramming innate immune cells to regulate inflammation.
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Scientists repurpose gene editing tool to help uncover hidden microbial diversity
Pioneering research has repurposed a gene editing tool to help shed light on the true biodiversity present in natural environments. The study could help pave the way for more productive soils and improved health.
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Microorganisms employ a secret weapon during metabolism
Microorganisms have evolved a variety of methods for fixing carbon. Researchers investigated the methods that are utilized at extremely hot, acidic and sulfur-rich hydrothermal vents in shallow waters off the island of Kueishantao, Taiwan.
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Cyanobacterium study reveals how circadian clocks maintain robustness in changing environments
New research has uncovered how a simple circadian clock network demonstrates advanced noise-filtering capabilities, enhancing our understanding of how biological circuits maintain accuracy in dynamic natural environments.
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A cocktail of drugs may work against a whole family of viruses
Enteroviruses cause everything from polio to meningitis. An effective treatment could help reduce the risk of this global health problem.
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Añana Saltern microorganisms help to clarify the groundwater flow pattern
The MicroIker group of the University of the Basque Country (UPV/EHU) has explored the diversity and distribution of unicellular organisms in the springs of the Añana Salt Valley.
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Coral reefs exude myriad chemicals, fueling dynamic microbial recycling of nutrients
New research reveals the remarkable chemical diversity of substances exuded by coral reefs and demonstrates that thousands of different chemicals derived from tropical corals and seaweeds are available for microbes to decompose and utilize.
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Engineered bacteria emit signals that can be spotted from a distance
Engineers have found a way to read out bacterial signals from as far as 90 meters away. This work could lead to the development of bacterial sensors for agricultural and other applications, which could be monitored by drones or satellites.
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Study finds immune protein modification blocks viral replication, heart inflammation
New research shows protein modifications to the immune sensor MDA5 reduce viral replication and may lead to broad-spectrum antiviral breakthroughs.
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Gut microbes could one day be deployed to tackle sleepless nights: review
Personalized pre/probiotic treatments could someday be used to support healthy sleep through stressful exam periods and menopause, a new review suggests.
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Researchers discover large dormant virus can be reactivated in model green alga
Scientists have not only found a virus in the green alga Chlamydomonas reinhardtii but discovered the largest one ever recorded with a latent infection cycle, meaning it goes dormant in the host before being reactivated to cause disease.