All COVID-19 articles – Page 5
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Scientists discover series of SARS-CoV-2 mpro inhibitors for potential COVID-19 treatments
New research has identified a novel series of SARS-CoV-2 Mpro inhibitors that may lead to potential new COVID-19 treatments that, according to preclinical testing, effectively inhibits COVID-19 and synergizes with existing anti-COVID therapies.
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Study finds persistent infection could explain long COVID in some people
Researchers found people with wide-ranging long COVID symptoms were twice as likely to have SARS-CoV-2 proteins in their blood, compared to those without long COVID symptoms.
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Researchers confront new US and global challenges in vaccinations of adults
Decreasing vaccination rates now threaten the huge beneficial impacts of vaccinations in the U.S. and globally. Researchers discuss the barriers including increasing vaccine hesitancy and new clinical and public health challenges in vaccinations of U.S. adults.
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Peptide acts as molecular shield to prevent SARS-CoV-2 from infecting cells
The synthetic peptide was inspired by ACE2, the protein to which the virus that causes COVID-19 binds to invade human cells. The results point to a route for the development of novel antivirals.
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New mouse models offer valuable window into COVID-19 infection
Scientists have developed six lines of humanized mice that can serve as valuable models for studying human cases of COVID-19 because their cells were engineered to include two important human molecules that are involved in infection of human cells.
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High-throughput modular click chemistry synthesis of catechol derivatives to target Covid protease
Researchers performed high-throughput synthesis of catechol derivatives from the bioactive catechol-terminal alkyne scaffold A4, by using modular click chemistry, in a bid to target the Covid virus’s 3C-like protease (3CLpro).
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Could a bout of COVID protect you from a severe case of flu?
More than 200 viruses can infect and cause disease in humans; most of us will be infected by several over the course of a lifetime. Does an encounter with one virus influence how your immune system responds to a different one?
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Study IDs novel small-molecule inhibitors of SARS-CoV-2 with chemical genetics
A new article discusses the identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics.
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Covid’s ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites
A new study discusses how SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites.
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Study charts spectrum of febrile rash illness in China from 2009 to 2021
A new study monitors the spectrum of viral pathogens involved in febrile rash illness (FRI) and their epidemiology.
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Analysis sheds light on COVID-19-associated fungal disease in Japan
Researchers in Japan pored through data to understand the incidence in Japan of COVID-19-associated pulmonary aspergillosis (CAPA), a severe invasive fungal infection of the lungs.
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New testing system using Janus particles rapidly and accurately detects COVID-19
Researchers have developed a new quantitative testing system called the ’Express Biochecker’, which provides a simple, rapid, and low-cost method for detecting the coronavirus N protein.
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Origami paper sensors could help early detection of infectious diseases in low-cost test
Researchers have developed an innovative new method for identifying biomarkers in wastewater using origami-paper sensors, enabling the tracking of infectious diseases using the camera in a mobile phone.
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Genetic tracing at the Huanan Seafood market supports COVID animal origins
A study provides a list of the wildlife species present at the market from which SARS-CoV-2 most likely arose in late 2019, based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC).
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Low-power laser can selectively detect coronavirus spike proteins in just five minutes
Researchers have demonstrated a method to detect the presence of viruses quickly, using only a small sample. The light-induced immunoassay coated with novel coronavirus spike proteins was highly sensitive even with weak light like a laser pointer.
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Antiviral-resistant variants of SARS-CoV-2 can emerge in immunocompromised people
Individuals with compromised immunity and persistent COVID-19 infections can harbor drug-resistant variants of the SARS-CoV-2 virus, which have the potential to spread to the general population.
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Study sheds light on how virus-fighting cells develop during long Covid
A new long-term study into long COVID has investigated how a certain population of white blood cells, called memory T cells, are established and develop as part of the body’s defense to fight off the disease.
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US COVID-19 rates show oscillating waves every six months
COVID-19 cases in the U.S. have shown unexpected oscillating waves every six months between the southern states and the northern states and, to a lesser degree, from east to west, according to new research.
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Scientists discover dual roles of antibodies in COVID-19 infections
A new study has discovered an antibody that can both assist and block a virus. This particular antibody helps pre-Omicron variants of the virus infect cells while preventing the Omicron variant from doing the same.
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It’s the unchanging parts of the Covid virus we also need to pay attention to, study suggests
A new study demonstrates the value of surveillance for public health initiatives, while identifying stable parts of the virus as potential candidates for small molecule drugs and other drug development.