All Bioengineering articles
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NewsTrust your gut to heal your brain
Researchers have found that short-term antibiotic treatment significantly reduced neuroinflammation and neurodegeneration following traumatic brain injury (TBI) by altering the gut microbiome in animal models.
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NewsA single gene, a dramatic change: CRISPR unlocks white strawberries
Researchers used CRISPR/Cas9 to selectively edit a single dominant gene copy controlling fruit color in the commercial octoploid strawberry cultivar ‘Florida Brilliance’. By targeting the MYB10-1B gene, they successfully converted red strawberries into stable white-fruited plants.
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NewsRhododendron-derived drugs now made by bacteria
Bioengineered E. coli bacteria can now produce a group of compounds with anticancer, anti-HIV, antidiabetic and anti-inflammatory activities. The compounds, orsellinic acid-derived meroterpenoids, are produced by Rhododendron species.
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NewsTechnology transfer for Corallopyronin A successfully completed with Phyton Biotech
Phyton Biotech has successfully transferred the manufacturing process for the microbial production of Corallopyronin A (CorA). CorA is a novel anti-infective agent with the potential to address neglected tropical diseases.
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NewsTaxiing through the gut: Formic acid in the microbiome
Scientists have found that the gut bacterium Blautia luti produces formic acid (formate) instead of carbon dioxide (CO₂) and hydrogen, with hydrogen bound to CO₂. In this case, formic acid is the electron taxi, allowing the energetically costly production of hydrogen to be bypassed.
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NewsGreen chemistry: Friendly bacteria can unlock hidden metabolic pathways in plant cell cultures
Co-culturing plant cells with harmless bacteria can expand the diversity of obtainable plant-derived compounds for pharmaceuticals, cosmetics, and agrochemicals, a new study shows.
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NewsGenetic system makes worker cells more resilient producers of nanostructures
Researchers report the development of a new genetic regulatory system to improve cell viability during the production of gas vesicles.
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NewsNaval Research Lab Space Station study reveals key challenges and opportunities for microbial biomanufacturing in space
Scientists have completed a spaceflight biology investigation aboard the International Space Station (ISS) that reveals how microgravity fundamentally alters microbial metabolism, limiting the efficiency of biological manufacturing processes critical to future long-duration space missions.
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NewsScientists synthesize medicarpin in baker’s yeast
Scientists have developed a way to synthesize medicarpin in yeast. Like palitaxel in the 1990s, this tumor-attacking sustance has only limited natural quantitites and is considered difficult to synthesize.
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NewsScientists engineer quantum-enabled proteins, opening a new frontier in biotechnology
A new study reports the creation of a new class of biomolecules, magneto-sensitive fluorescent proteins, that can interact with magnetic fields and radio waves. This is enabled by quantum mechanical interactions within the protein, and occur when it is exposed to light of an appropriate wavelength.
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NewsGame-changer for rare sugars: alkaline media unlocks high yield of rare sugars from bacteria
Bacterial EPSs (exopolysaccharides) are emerging as a sustainable source of rare sugars, offering advantages including higher yields and lower environmental impact.
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NewsScientists reprogramme E. coli to transform sugars into eco-friendly surfactant
A new study demonstrates a sustainable microbial strategy for producing lauryl glucoside by engineering a non-natural biosynthetic pathway in Escherichia coli, revealing precursor availability as a key bottleneck and moving towards greener biomanufacturing.
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NewsGolden Gate method enables rapid, fully-synthetic engineering of therapeutically relevant bacteriophages
Researchers have described the first fully synthetic bacteriophage engineering system for Pseudomonas aeruginosa. In this method, researchers engineer bacteriophages synthetically using sequence data rather than bacteriophage isolates.
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NewsBrewing a rare medicine: yeast engineered to produce a valuable astragalus isoflavonoid
By reconstructing the complete biosynthetic pathway inside Saccharomyces cerevisiae and systematically removing metabolic bottlenecks, researchers created the first yeast platform capable of producing calycosin-7-glucoside from simple carbon sources.
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NewsReconstructing nature’s oxindole factory: yeast-based biosynthesis of medicinal indole alkaloids
By identifying four key enzymes from a North American plant and reconstituting them in yeast, scientists have achieved complete de novo biosynthesis of complex oxindole molecules that are difficult to obtain from plants or chemical synthesis.
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NewsEngineered yeast delivers record levels of animal-free chondroitin sulfate
A new study establishes a robust yeast-based platform that overcomes the long-standing trade-off between yield and sulfation, enabling sustainable, high-level production of high-quality chondroitin sulfate without reliance on animal sources.
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NewsEngineering yeast to make rare anticancer saponins: reconstructing the complete biosynthesis of polyphyllin II
By combining plant transcriptomics, enzyme engineering, and synthetic biology, a new study demonstrates, for the first time, the full heterologous production of polyphyllin II in Saccharomyces cerevisiae.
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NewsScientists develop new biosynthetic route to optically pure S-2-Hydroxyisovalerate
By uncovering an unexpected enzyme activity and combining it with precise metabolic engineering, scientists has transformed Escherichia coli into a microbial factory capable of producing gram-per-liter levels of optically pure S-HIV from renewable carbon sources.
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NewsExploring metabolic noise opens new paths to better biomanufacturing
Engineers investigating fluctuating metabolic activity in microorganisms have developed tools to keep every microbial cell at peak productivity during biomanufacturing.
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NewsProbiotic living microneedles designed by interbacterial competition for accelerated infected wound healing
Probiotic therapy offers a promising strategy for chronic infected wound management. Inspired by bacterial competitive interactions, researchers developed a multifunctional microneedle (MN) platform to overcome the limitations of weak competitiveness and poor penetration across biofilm barriers.