All Antimicrobials articles – Page 2
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News
New study looks at drug exposures of COVID-19 therapy for pregnant women
A new study provides important insights into the pharmacokinetics and safety of intravenous remdesivir in treating the SARS-CoV-2 coronavirus in pregnant women.
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Infected bacteria fight back with ‘hidden’ genes that halt cell growth, slow viral spread
Researchers have uncovered a surprising way bacteria defend themselves: when a bacterium is infected, bacterial enzymes that copy genetic information from RNA into DNA synthesize genes whose protein products help shut down cell growth.
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Super cally molecules take down tuberculosis
Researchers have identified and synthesised a group of molecules that can act against the cause of tuberculosis in a new way. The callyaerins act against TB by employing a fundamentally different mechanism compared to antibiotic agents used to date.
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New compound found to be effective against flesh-eating bacteria
Researchers have developed a novel compound that effectively clears bacterial infections in mice, including those that can result in rare but potentially fatal ‘flesh-eating’ illnesses, and could be the first of an entirely new class of antibiotics.
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Human clinical study launched using phage lysin to eliminate staph in the nasal microbiome
A “first-in-human” study with the novel drug candidate HY-133 began on 10 July with the recruitment of clinically healthy volunteers who tested positive for Staphylococcus aureus colonisation of the nose.
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Copper oxide nanoparticles to counter pathogens are synthesized from mango
Researchers have synthesized green copper oxide nanoparticles from Mangifera indica leaf extract. They showed potent activity against gram-positive and negative bacteria, as well as fungicidal effects on persimmon fruit pathogens.
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Harnessing big data helps scientists hone in on new antimicrobials
Scientists have detailed a new method of identifying antimicrobial enzymes from large datasets of bacterial proteins, which could provide a solution to antibiotic resistance.
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Careers
Drug discovery and a valuable chance to network: Ugochukwu Anieto on a fascinating experience at ASM 2024
Professor Ugochukwu Anieto of Texas A&M University reveals how AMI’s Scientific Event Travel Grant helped him to gather some fascinating insights on antimicrobial compounds at the recent ASM conference.
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Careers
Connecting with microbiologists and presenting research: Oluwole Owoyemi reports back from ASM 2024
Medical microbiologist Oluwole Owoyemi of Achievers University Owo and Federal University of Technology, Akure, reports back from ASM MICROBE 2024 after being awarded a Scientific Event Travel Grant by Applied Microbiology International.
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Treatment with a mixture of antimicrobial peptides can impede antibiotic resistance
A common infection-causing bacteria was much less likely to evolve antibiotic resistance when treated with a mixture of antimicrobial peptides rather than a single peptide, making these mixtures a viable strategy for new antibiotic treatments.
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Marine natural product derivative offers new therapeutic strategy to inhibit enterovirus A71 replication
Researchers revealed that the inhibition of enterovirus A71 (EV-A71) replication can be achieved by targeting the human coatomer subunit zeta-1 (COPZ1) using a marine natural product derivative known as MPA-CF3.
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SKAN Research Trust and Quadram Institute Bioscience to develop novel microbial therapies
SKAN Research Trust and Quadram Institute Bioscience will apply the TraDIS-Xpress platform to study the action of traditional medical compounds on bacteria, aiding in the reformulation and development of novel antibacterial regimens.
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WHO releases report on state of development of antibacterials
Although the number of antibacterial agents in the clinical pipeline increased from 80 in 2021 to 97 in 2023, there is a pressing need for innovative agents for serious infections and to replace those becoming ineffective due to widespread use, the WHO says.
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Wooden surfaces may have natural antiviral properties - and the species matters
Wood has natural antiviral properties that can reduce the time viruses persist on its surface — and some species of wood are more effective than others at reducing infectivity.
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Innovative phage lysin HY-133 enters phase I clinical study
HYpharm’s innovative preventive agent HY-133 has reached the first clinical trial phase. HY-133 is specifically effective against Staphylococcus aureus including multi-resistant strains and is intended to combat its colonisation in the nose.
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Uncovering the potential of ‘golden flower’ and its fermentation application in tea
A new review examines the biological characteristics and fermentation applications of Eurotium cristatum, commonly known as the ’golden flower’, a dominant microbial strain in the fermentation process of Fu brick tea.
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Water-soluble version of bacterial enzyme may help researchers develop new antibiotics
Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics.
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Novel lipopeptide produced by bacterium proves lethal against Staphylococcus aureus
A novel antibacterial lipopeptide produced by the bacterium Serratia marcescens has been shown to be highly effective in killing Staphylococcus aureus – one of the most important pathogens occurring in humans.
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World famous Roman Baths could help scientists counter antibiotic resistance
The world-famous Roman Baths are home to a diverse range of microorganisms which could be critical in the global fight against antimicrobial resistance, a new study suggests.
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Newly isolated antibodies may aid effort to fight influenza B
Researchers have isolated human monoclonal antibodies against influenza B, a significant public health threat that disproportionately affects children, the elderly and other immunocompromised individuals.